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- This review examines the causes of headaches in patients with acromegaly and how various treatments for the condition affect headache symptoms.
- Headaches occur in 30-70% of acromegaly patients due to factors such as the tumor itself, hormonal changes, and other underlying issues, necessitating careful diagnosis and management.
- Despite treatments like surgery and medication normalizing hormone levels, headaches may still persist, highlighting the need for specialized headache management for these patients.
Expression of the apelin system in the porcine pituitary during the oestrous cycle and early pregnancy and the effect of apelin on LH and FSH secretion.
Theriogenology
December 2024
Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719, Olsztyn, Poland. Electronic address:
Reproductive success requires considerable energy investment. Research has shown that some adipokines, i.e.
View Article and Find Full Text PDFPrior studies show that disrupting somatotropic axis components extends laboratory mouse lifespan, but confounding effects of additional genes and hormones obscure the specific impact of growth hormone (GH) on longevity. We address this issue by using mice with a specific knockout of the GH gene, revealing that disrupting GH alone substantially increases lifespan. The longevity effects are accompanied by altered metabolic fuel utilization, directly linking GH action to aging mechanisms.
View Article and Find Full Text PDFEarly Life Interventions: Impact on Aging and Longevity.
Aging Dis
August 2024
Division of Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Article Synopsis
- Lifespans in mammals can differ significantly, with developmental speed being inversely related to lifespan, suggesting early-life interventions (ELIs) could modify aging patterns.
- This review examines how various postnatal interventions in mice, such as diet changes and chemical treatments, impact development and lifespan, highlighting significant changes in aging processes.
- Understanding the complexities of ELI research requires careful experimental design and attention to factors like timing and sex differences, which can inform future strategies for promoting healthy aging.
Paracrine FGF1 signaling directs pituitary architecture and size.
Proc Natl Acad Sci U S A
October 2024
Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Organ architecture is established during development through intricate cell-cell communication mechanisms, yet the specific signals mediating these communications often remain elusive. Here, we used the anterior pituitary gland that harbors different interdigitated hormone-secreting homotypic cell networks to dissect cell-cell communication mechanisms operating during late development. We show that blocking differentiation of corticotrope cells leads to pituitary hypoplasia with a major effect on somatotrope cells that directly contact corticotropes.
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