Seriated ferritin assays were carried out on 95 patients affected by primitive ovarian epithelial tumour over a period of three years (1979/82), by radioimmunometric assay for human spleen ferritin. Ferritin was elevated in endometrioid tumours and in the presence of active progressing disease and chemotherapy did not influence these values. The ferritin/sideremia ratio was high in the case with pathological levels. Studying the glicosilation of this protein a significant amount of ferritin was not bound to concavallin A, suggesting direct release of this protein by tumour cells.
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Preoperative evaluation of ferritinemia in primary epithelial ovarian cancer.
Tumori
April 1998
First Department of Obstetrics and Gynecology, University Medical School, Bari, Italy.
Aims And Background: High ferritin serum levels have been reported in patients suffering from various malignancies. The aim of this study was to evaluate the role of ferritinemia in the preoperative diagnosis of ovarian carcinoma.
Methods: Between March 1993 and September 1996, 60 patients suffering from ovarian carcinoma were surgically treated at our Department.
Seriated ferritin assays were carried out on 95 patients affected by primitive ovarian epithelial tumour over a period of three years (1979/82), by radioimmunometric assay for human spleen ferritin. Ferritin was elevated in endometrioid tumours and in the presence of active progressing disease and chemotherapy did not influence these values. The ferritin/sideremia ratio was high in the case with pathological levels.
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