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Acute Hepatitis Related to Hepatitis E Virus Genotype 3f Infection in Brazil.

J Med Virol

November 2024

Laboratório de Gastroenterologia e Hepatologia Tropical, LIM-07, Instituto de Medicina Tropical, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Article Synopsis
  • * In group 1 (44 patients with acute hepatitis A), 4% tested positive for HEV IgM and 14.5% for IgG, while in group 2 (47 patients with non-A-C AH), these rates were 4.3% for IgM and 14.9% for IgG; only one sample from group 2 tested positive for HEV RNA.
  • * The findings suggest HEV should be considered in non-A-C acute hepatitis cases, particularly as one patient with HEV recently traveled to a high-serop
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Article Synopsis
  • * A study in eastern Iran found that 58.2% of hemophilia patients had SENV, compared to 20% in healthy individuals, with the highest prevalence in type A and severe cases.
  • * The results emphasize the need for ongoing monitoring of SENV in hemophilia patients due to its significant presence and potential health complications.
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Development and implementation of assays to monitor human adenovirus F40/41 in wastewater: Trends preceding, during, and following the non-A-to-E hepatitis outbreak in Stockholm.

Environ Int

August 2024

Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Center, SE-10691 Stockholm, Sweden.

Human adenovirus (HAdV) type F41 has been identified as a possible cause of the non-A-to-E hepatitis outbreak. This study uses wastewater monitoring to track HAdV F40 and F41, supporting clinical investigations and providing insights into the pathogen's role in the outbreak. Given the limited clinical monitoring in Sweden of HAdV-F40/41, this approach also helps estimate the true infection burden of this pathogen during the outbreak.

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Background And Aims: Non-A-E hepatitis (NAEH) not leading to acute liver failure (ALF) is poorly documented. The objective was to compare clinical and laboratory features of uncomplicated acute NAEH with acute viral (AVH) and autoimmune hepatitis (AIH) and histopathology in NAEH and AIH.

Methods: Cases of hepatocellular jaundice were included.

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Tracing the History of Hepatitis E Virus Infection in Mexico: From the Enigmatic Genotype 2 to the Current Disease Situation.

Viruses

September 2023

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

Hepatitis E virus (HEV) is the major cause of acute viral hepatitis worldwide. This virus is responsible for waterborne outbreaks in low-income countries and zoonosis transmission in industrialized regions. Initially, considered self-limiting, HEV may also lead to chronic disease, and evidence supports that infection can be considered a systemic disease.

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