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Population pharmacokinetics of bedaquiline: a systematic review.
Eur J Clin Pharmacol
January 2025
Department of Pharmacy, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, 310000, Zhejiang, China.
Background And Objectives: Bedaquiline (BDQ) plays a critical role in the treatment of multidrug-resistant tuberculosis (MDR-TB). However, the large pharmacokinetic (PK) variability of BDQ presents a significant challenge in its clinical use. This study aimed to summarize the population PK characteristics of BDQ and to identify significant covariates affecting the PK variation of BDQ.
View Article and Find Full Text PDFReplacing rifampicin with minocycline increases the activity of the treatment regimen for Mycobacterium avium complex pulmonary disease in a dynamic hollow-fibre system.
Int J Antimicrob Agents
December 2024
Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:
Mycobacterium avium complex bacteria cause chronic pulmonary disease (MAC-PD) in susceptible patients [1]. The recommended treatment regimen (rifampicin, ethambutol and azithromycin) achieves 65% cure rates but with considerable toxicity and drug-drug interactions [2,3]. Minocycline proved active in monotherapy experiments using the hollow-fibre model [4].
View Article and Find Full Text PDFUnravelling the challenge of cotrimoxazole and rifampin resistance in B. melitensis and B. abortus: A systematic review and meta-analysis.
PLoS Negl Trop Dis
December 2024
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Brucellosis, caused by B. abortus and B. melitensis, is a significant health threat, and standard treatments like rifampin and cotrimoxazole are facing rising antibiotic resistance.
- A systematic review analyzed 59 studies from 21 countries, revealing that cotrimoxazole resistance is at 3.4% and rifampin resistance at 4.6%, with trends showing increases over time, especially in B. melitensis.
- The study underscores the need for ongoing monitoring of antibiotic resistance, highlighting variations based on time, geography, and species, to inform treatment guidelines for pediatric brucellosis.
Formulation, Characterisation, and Biocompatibility Assessment of Rifampicin-Loaded Poly(d,l-lactide-co-glycolide) Composites for Local Treatment of Orthopaedic and Wound Infections.
Pharmaceutics
November 2024
School of Chemistry and Biosciences, University of Bradford, Bradford BD7 1DP, UK.
The escalating challenge of antimicrobial resistance (AMR) necessitates the development of targeted antibiotic delivery platforms, minimising systemic administration. Polymer-based drug delivery emerges as a promising solution, ensuring sustained release and prolonged efficacy of bioactive compounds, ensuring long-term efficacy. This study focuses on encapsulating rifampicin (RIF), a key antibiotic for orthopaedic and wound-related infections, within Poly(d,l-lactide-co-glycolide) (PLGA), a biodegradable polymer, through solvent casting, to formulate a PLGA-RIF composite membrane.
View Article and Find Full Text PDFStructure of a Cyclic Peptide as an Inhibitor of Transcription: NMR and Molecular Dynamics Simulations.
Pharmaceuticals (Basel)
November 2024
Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.
Background And Objectives: A novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase (RNAP) of (MTB). This peptide inhibits RNA elongation in the MTB transcription initiation assay in the nanomolar range, which can halt the MTB transcription initiation complex, similar to RIF. Therefore, determining the solution conformation of this peptide is useful in improving the peptide's binding affinity to the RNAP.
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