Thyrotropin (TTH) and prostaglandin E2 (PGE2) interaction was studied, using the euthyroid paranodal tissue (isolated by sub-surgery) of the thyroid in patients with nodose goiter. Two types of specific binding, differing by the affinity and ligand-bound capacity, were discovered both for TTH and PGE2. The appropriate kinetic characteristics were analysed. The data concerning a possible PGE2 receptor localization on the external side of the thyrocyte plasma membrane were obtained by means of affinity chromatography. A precise relationship between specific TTH-PGE2 binding and human thyroid cells was revealed.
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