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Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway.
Sci Rep
January 2025
School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, No.461 Bayi Road, Donghu District, Nanchang, 330006, Jiangxi Province, People's Republic of China.
As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women's health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable of preventing estrogen-related diseases. Here, we aimed to investigate whether SDG can counteract cyclophosphamide (CTX) induced premature ovarian insufficiency (POI) and further explore its specific molecular mechanism.
View Article and Find Full Text PDFDilong (Earthworm) alleviates cyclophosphamide-induced brain injury by reducing mitochondrial damage in neuronal cells.
Neuroscience
December 2024
College of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, China; Traditional Chinese Veterinary Research Institute, Southwest University, Rongchang, Chongqing 402460, China. Electronic address:
The experiment was designed to explore the effects and mechanism of Dilong on alleviating cyclophosphamide (CTX)-induced brain injury in mice. Fifty male SPF Kunming mice aged 6-8 weeks were randomly divided into five groups: Group A served as the control group; Group B received intraperitoneal injection of CTX; Groups C, D, and E were administered Dilong at doses of 100, 200, and 400 mg/kg respectively for 14 days after intraperitoneal injection of CTX. Results showed that after modeling, the movement speed of mice significantly decreased (P < 0.
View Article and Find Full Text PDFModulatory action of Bryonia alba on the immune system in cyclophosphamide induced immunosuppression in BALB/c mice.
PLoS One
December 2024
Drug Standardization, Central Council for Research in Homoeopathy, New Delhi, India.
Article Synopsis
- Oxidative stress and inflammation are key issues in immune-compromised diseases and cancer treatments, prompting a study on the immune-boosting effects of Bryonia alba (BA) in mice with induced immune deficiency.
- The research involved treating BALB/c mice with various potencies of BA after cyclophosphamide administration, resulting in significant improvements in immune parameters like RBC and WBC levels, and increased expression of important immune cytokines.
- Histopathology showed that BA-treated mice maintained healthy spleen structures compared to those damaged by cyclophosphamide, suggesting BA's potential as an effective immunostimulant during chemotherapy, but more studies are needed on its effects against immune-compromised infections.
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Stem Cell Res Ther
December 2024
Reproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, No. 20 Zhengdong Road, Zhenjiang, Jiangsu Province, 212001, China.
Background: Premature ovarian insufficiency (POI) is an ovarian dysfunction disorder that significantly impacts female fertility. Ovarian granulosa cells (GCs) are crucial somatic components supporting oocyte development that rely on glycolysis for energy production, which is essential for follicular growth. Hypoxia-induced exosomal circRNAs regulate glycolysis, but their biological functions and molecular mechanisms in POI are largely unexplored.
View Article and Find Full Text PDFThe Role of lncRNAs in the Protective Action of Tamoxifen on the Ovaries of Tumor-Bearing Rats Receiving Cyclophosphamide.
Int J Mol Sci
November 2024
Department of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Infertility due to ovarian toxicity is a common side effect of cancer treatment in premenopausal women. Tamoxifen (TAM) is a selective estrogen receptor modulator that prevented radiation- and chemotherapy-induced ovarian failure in preclinical studies. In the current study, we examined the potential regulatory role of long noncoding RNAs (lncRNAs) in the mechanism of action of TAM in the ovaries of tumor-bearing rats receiving cyclophosphamide (CPA) as cancer therapy.
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