In order to clarify the age-related changes in serum 17-hydroxyprogesterone (17-OHP) secretion in men, serum basal 17-OHP levels were determined in 203 healthy male subjects from 10 months to 116 years of age, and serum 17-OHP responses to dexamethasone (Dex), fluoxymesterone (FM), HCG and ACTH were compared between the young and elderly groups. The mean basal 17-OHP level remarkably increased from pubescence to the third decade and gradually decreased with advance in age after fifty. Basal serum 17-OHP level was correlated more closely with serum testosterone (T) than cortisol (F), and was suppressed more remarkably after the administration of FM than Dex in both groups. Serum 17-OHP increased with 2 peaks at 6 and 24 hours after HCG injection, and serum 17-OHP response to HCG was significantly greater in the young than in the elderly group. Furthermore, in the aged subjects with low serum T levels, serum 17-OHP response to HCG was remarkably decreased. Within 3 hours after ACTH injection, serum 17-OHP response to ACTH was significantly lower in the elderly than in the young group. On the other hand, 12 hours after ACTH administration, serum 17-OHP response was remarkably greater in the elderly group, and the F/17-OHP ratio was significantly lower than in the young. These data indicate a decline of Leydig cell function in the testis of the elderly male and also suggest the occurrence of enzyme deficiencies, especially impaired C17, 20 lyase activity, in adrenal steroid hormone synthesis with aging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1507/endocrine1927.59.1_20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adrenal adenoma secreting 17-hydroxyprogesterone mimicking non-classical 21-hydroxylase deficiency.
Front Endocrinol (Lausanne)
December 2024
Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
In adrenal steroidogenesis, 17-hydroxyprogesterone (17-OHP) is a substrate for 21-hydroxylase, one of the crucial enzymes of the cortisol and aldosterone biosynthesis pathway. Thus, measurement serum 17-OHP concentration is used when the diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is suspected. In the classic 21-hydroxylase deficiency, randomly timed measurements of 17-OHP are generally significantly elevated using different immunoassays.
View Article and Find Full Text PDFNeonatal reference intervals for serum steroid hormone concentrations measured by LC-MS/MS.
Clin Chem Lab Med
October 2024
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Location University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Objectives: Congenital adrenal hyperplasia (CAH) is a rare, inherited disorder of adrenal steroid synthesis. In many countries it is part of the neonatal screening program enabling early diagnosis and treatment. In case of an abnormal neonatal screening result or when other differences of sexual development (DSD) are suspected, measurement of serum steroid hormones using liquid chromatography coupled to mass spectrometry (LC-MS/MS) is needed for further diagnosis.
View Article and Find Full Text PDFCan serum 17-hydroxy progesterone predict an improvement in semen parameters following micro-varicocelectomy? A prospective study.
Arch Ital Urol Androl
October 2024
Department of Andrology & STDs, Kasr Alainy Faculty of Medicine, Cairo University.
Background & Objectives: Notably, 17-hydroxy progesterone (17-OHP) (17-OHP) is a precursor for testosterone (T) synthesis, and intratesticular testosterone (ITT) is essential for spermatogenesis. Varicocele (Vx) has an estimated prevalence of 15% in the general population and 35% in those with primary infertility. We aimed to evaluate the correlation between changes of serum 17-OHP after sub-inguinal micro-varicocelectomy and improvement of semen parameters.
View Article and Find Full Text PDFCongenital Adrenal Hyperplasia: Experience from Dhaka Shishu (Children) Hospital, Bangladesh.
Mymensingh Med J
October 2024
Dr Rabi Biswas, Associate Professor, Department of Pediatric Endocrinology and Metabolic Disorders, Bangladesh Institute of Child Health and Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh; E-mail:
Article Synopsis
- There is limited data on congenital adrenal hyperplasia (CAH) in Bangladesh, prompting a study to gather information and identify key issues related to the condition.
- The analysis focused on 60 pediatric patients from Dhaka Shishu Hospital, revealing that 66.7% had salt-wasting form, with significant misassignments in gender at initial presentation.
- The study highlights the need for earlier CAH diagnosis to prevent severe health crises and emphasizes raising awareness for effective case identification and referral in resource-limited settings.
Hyperandrogenic eumenorrheic NON-PCOS women women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone.
J Clin Transl Endocrinol
September 2024
The Experts Group on Inositol in Basic and Clinical Research and on PCOS (EGOI-PCOS), 00161 Rome, Italy.
The subject of polycystic ovary syndrome (PCOS) has been extensively covered in the literature; however, there is a paucity of data regarding eumenorrheic women with hyperandrogenism and/or hyperandrogenemia without ultrasound evidence of PCO morphology (EuHyperA), and even less data on the comparison between PCOS and EuHyperA subjects. It has previously been shown that around half of PCOS women exhibit a hyper-response of serum 17-hydroxy-progesterone (17-OHP) to the stimulation by GnRH-agonists, also indicated as functional ovarian hyperandrogenism (FOH). Often, this stimulation test is preceded by suppression of the adrenal steroidogenesis with oral dexamethasone (Dex).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!