AI Article Synopsis
- Researchers found specific binding sites for GABA in the membrane of rat oviducts, suggesting the presence of GABA receptors.
- The binding of [3H]GABA could be blocked by unlabelled GABA, muscimol, and bicuculline, indicating these substances interact with the same receptors.
- GABA and muscimol increased cyclic AMP levels in oviduct slices, showing that GABA receptors play a significant functional role in the oviduct.
Article Abstract
A low concentration of high-affinity, saturable and specific [3H]GABA binding sites has been identified in a membrane fraction of rat oviduct. The specific binding of [3H]GABA was displaced by unlabelled GABA, muscimol and bicuculline. Furthermore in oviductal slices, GABA and a known GABA receptor agonist, i.e. muscimol, produced a significant elevation of cyclic AMP levels, which could be antagonized by GABA receptor blockers, i.e. picrotoxin and bicuculline. The present results indicate that GABA receptors may have a functional significance in rat oviduct.
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| http://dx.doi.org/10.1016/0304-3940(82)90384-6 | DOI Listing |
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