The value of a breast surgery procedure based on clinical examination, mammography, telethermography, echotomography and cytological examination for the diagnosis of symptomatic or high risk patients was tested through a retrospective survey of 28 patients with minimal breast cancer. The data confirm that mammography is a much better clinical and instrumental test than other systems. When associated with radiography it gives definite, early diagnosis of more breast neoplasias than other methods, facilitating prognosis and reducing the number of biopsies necessary.
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Aesthetic Plast Surg
January 2025
Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Background: In implant-based breast surgery, microbial contamination of implant surfaces predisposes complications such as overt periprosthetic infection and has been linked to capsular contracture (CC). Anti-microbial practices, including povidone-iodine (PVP-I) breast pocket irrigation, are routinely employed to minimise these risks. No standardised protocol for using this antiseptic exists, particularly concerning the ideal concentration.
View Article and Find Full Text PDFSci Rep
January 2025
Division of Hematology and Oncology, University of California, 1450 3rd Street, San Francisco, CA, 94143, USA.
For individuals at high risk of developing breast cancer, interventions to mitigate this risk include surgical removal of their breasts and ovaries or five years treatment with the anti-estrogen tamoxifen or aromatase inhibitors. We hypothesized that a silicone based anti-estrogen-eluting implant placed within the breast would provide the risk reduction benefit of hormonal therapy, but without the adverse effects that limit compliance. To this end, we demonstrate that when placed adjacent to mammary tissue in the 7,12-dimethylbenz[a]anthracene-induced rat breast cancer model a fulvestrant-eluting implant delays breast cancer with minimal systemic exposure.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.
This study explores the development of a sustainable drug delivery system using cellulose nanoparticles (CNPs) derived from potato pulp for the controlled release of phosphoaminopyrazine (PAP), a promising anticancer agent. CNPs were synthesized via nanoprecipitation, and PAP was loaded through in-situ nanoprecipitation, achieving a high loading efficiency of 79.2 %.
View Article and Find Full Text PDFBiomaterials
January 2025
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, PR China; Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, 310058, PR China; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China.
Nowadays, photodynamic therapy (PDT) offers a non-invasive tumor treatment with high safety profiles and minimal side effects, implying a promising clinical application for patients with malignant tumors. However, the lack of efficacy in metastasis and recurrence still notably limits its application. To solve this problem, one promising strategy is to improve the immune response activated by PDT.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
President Office, Tung Wah College, Hong Kong SAR, People's Republic of China.
Aims: To synthesise evidence on decision regret about treatment amongst women with early breast cancer, including (1) the type of treatment related to decision regret, (2) the level of decision regret, and (3) factors associated with decision regret.
Design: Integrative review.
Methods: Studies published between January 2000 and December 2023 were searched from five online databases to provide up-to-date evidence.
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