The authors report their experience in the treatment of advanced scirrhous carcinoma of the breast with estrogens only at the Curie Institute. Patients were elderly women in whom other forms of treatment were contraindicated because of local tumor extension or a poor general condition related to age. 32.5% of the patients responded favorably (out of a total of 40 patients). Mean duration of treatment was 21.5 months. Dosage varied according to efficacy and side-effects. Both dienestrol and diethylstilbestrol were used with no preference for one or the other. Serious side-effects were relatively infrequent and minor side-effects either resolved or improved significantly when dosage was reduced or treatment discontinued. Considering the present widespread use of antiestrogens and the systematic detection and dosage of intratumoral hormone receptors, the authors stress the advantages of this seemingly paradoxical effect of estrogens and underline the need for comparative studies.
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Chronological changes in etiology, pathological and imaging findings in primary liver cancer from 2001 to 2020.
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Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Purpose: To achieve a historical perspective, the chronological changes in primary liver cancer over a 20-year period were investigated at a single institution, focusing on shifts in etiology and the impact on imaging and pathological findings using The Liver Imaging Reporting and Data System.
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View Article and Find Full Text PDF[Hepatocellular carcinoma: Histological and molecular classifications].
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Université Paris Cité, Paris, France; Département de pathologie, FHU MOSAIC, SIRIC InSitu, hôpital Beaujon, AP-HP. Nord, Clichy, France; Centre de recherche sur l'inflammation, Inserm, UMR 1149, Paris, France.
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Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address:
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Comment to "An unusual "linitis plastica" like breast cancer bladder metastasis".
Arch Ital Urol Androl
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Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genoa; IRCCS Ospedale Policlinico San Martino, Genoa.
Dear Editor, We read with interest the recently published article by Farci et al., titled "An unusual 'linitis plastica' like breast cancer bladder metastasis" and we congratulate the authors for the very interesting topic and case presented..
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