The authors have used histochemical techniques to identify lymphocytic infiltrations in the rheumatoid nodule. They used the technique of alpha-naphtyl-acetate esterase (ANAE) for macrophages, ANAE plus Sodium Fluoride (NaF) for T-lymphocytes and 5-nucleotidase for B-lymphocytes. The results of this study reveal that the lymphocytic component of the rheumatoid nodule is mostly B-lymphocytes.
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