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Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.
Proc Natl Acad Sci U S A
November 2024
MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824.
Carboxysomes are protein microcompartments found in cyanobacteria, whose shell encapsulates rubisco at the heart of carbon fixation in the Calvin cycle. Carboxysomes are thought to locally concentrate CO in the shell interior to improve rubisco efficiency through selective metabolite permeability, creating a concentrated catalytic center. However, permeability coefficients have not previously been determined for these gases, or for Calvin-cycle intermediates such as bicarbonate ([Formula: see text]), 3-phosphoglycerate, or ribulose-1,5-bisphosphate.
View Article and Find Full Text PDFPrognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer.
Prz Menopauzalny
June 2024
Medical Chemistry Department, College of Medicine, University of AL-Qadisiyah, Al- Diywaniyah, Iraq.
Article Synopsis
- Breast cancer is the most common cancer among women globally, and this study focused on understanding the role of an enzyme called PHGDH and the amino acid glycine in breast cancer patients.
- The study was conducted between December 2022 and March 2023, analyzing blood samples from 65 breast cancer patients and 70 healthy controls to measure levels of PHGDH and glycine, along with a complete blood count.
- Results indicated that breast cancer patients had a significantly lower level of PHGDH and a higher level of glycine compared to healthy women, suggesting that these factors could help in assessing cancer progression.
Landscape of glycolytic metabolites and their regulating proteins in myocardium from human heart failure with preserved ejection fraction.
Eur J Heart Fail
September 2024
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) reflects half of all clinical HF yet has few therapies. Obesity and diabetes are now common comorbidities which have focused attention towards underlying myocardial metabolic defects. The profile of a major metabolic pathway, glycolytic intermediates and their regulating enzymes and ancillary pathways, remains unknown.
View Article and Find Full Text PDFRegulation of Rubisco activity by interaction with chloroplast metabolites.
Biochem J
August 2024
Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, U.K.
Rubisco activity is highly regulated and frequently limits carbon assimilation in crop plants. In the chloroplast, various metabolites can inhibit or modulate Rubisco activity by binding to its catalytic or allosteric sites, but this regulation is complex and still poorly understood. Using rice Rubisco, we characterised the impact of various chloroplast metabolites which could interact with Rubisco and modulate its activity, including photorespiratory intermediates, carbohydrates, amino acids; as well as specific sugar-phosphates known to inhibit Rubisco activity - CABP (2-carboxy-d-arabinitol 1,5-bisphosphate) and CA1P (2-carboxy-d-arabinitol 1-phosphate) through in vitro enzymatic assays and molecular docking analysis.
View Article and Find Full Text PDFThe primary carbon metabolism in cyanobacteria and its regulation.
Front Plant Sci
July 2024
Department Plant Physiology, University of Rostock, Rostock, Germany.
Cyanobacteria are the only prokaryotes capable of performing oxygenic photosynthesis. Many cyanobacterial strains can live in different trophic modes, ranging from photoautotrophic and heterotrophic to mixotrophic growth. However, the regulatory mechanisms allowing a flexible switch between these lifestyles are poorly understood.
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