AI Article Synopsis
- A randomized trial involving 153 patients with stage III malignant epithelial tumors compared the effectiveness of irradiation alone versus a combination of chemotherapy and irradiation.
- No significant differences in prognosis or operability were observed between the two treatment methods, but 41% of patients initially deemed inoperable underwent successful surgery after treatment.
- The study found that preoperative irradiation improved surgical outcomes, and both the size of the residual tumor and its grade significantly impacted patient survival rates.
Article Abstract
A prospective randomized trial was carried out in 153 patients with stage III malignant epithelial tumours for comparing the effects of irradiation or combination of chemotherapy and irradiation on prognosis and operability. No significant differences between these two treatment modalities were found. Of the patients primarily considered inoperable were 41 per cent operated upon after preoperative treatment. Minimum residual disease (0 to less than or equal to 2 cm) occurred in 38 per cent of the primarily operated and in 31 per cent of those operated upon after preoperative treatment. Preoperative irradiation in primarily inoperable patients enabled more effective surgical measures at relaparotomy. The size of the residual tumour after surgery and the tumor grade influenced the survival.
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| http://dx.doi.org/10.3109/02841868209134003 | DOI Listing |
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