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Morphological Characteristics and Extracellular Matrix Abnormalities in Astrocytes Derived From iPSCs of Children With Alexander Disease.
CNS Neurosci Ther
January 2025
Children's Medical Center, Department of Pediatric Neurology, Peking University First Hospital, Beijing, China.
Aims: Alexander disease (AxD) is a leukodystrophy caused by mutations in the astrocytic filament gene GFAP. There are currently no effective treatments for AxD. Previous studies have rarely established AxD models with the patient's original GFAP mutations.
View Article and Find Full Text PDFThree Years of Progression-free after Biopsy of BRAF V600E-negative Ganglioglioma in the Adult Brainstem: A Case Report and the Literature Review.
NMC Case Rep J
December 2024
Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan.
Ganglioglioma, a glioneuronal neoplasm, typically presents in adolescents' temporal lobes. While pediatric brainstem gangliogliomas (BSGGs) are well documented, adult BSGGs are limited, resulting in a lack of comprehensive understanding of their pathophysiology and prognosis. A 41-year-old woman who presented with dizziness and numbness in her right upper extremity and right face underwent radiological examination.
View Article and Find Full Text PDFEstablishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice.
Int J Mol Sci
November 2024
Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo 409-3898, Japan.
Alexander disease (AxD) is an intractable neurodegenerative disease caused by mutations in (), which is predominantly expressed in astrocytes. Thus, AxD is a primary astrocyte disease. However, it remains unclear how mutations affect astrocytes and cause AxD pathology.
View Article and Find Full Text PDFCocoon microstructures through the lens of topological persistence.
J R Soc Interface
November 2024
University of Potsdam, Institute for Mathematics, Potsdam 14476, Germany.
Article Synopsis
- Biological materials, like silkworm cocoons, have complex microstructures that affect their functions.
- New geometric and topological strategies are used to analyze these microstructures accurately.
- The article highlights how topological persistence and geometric methods help examine X-ray scans of cocoons, revealing insights about pore spaces, silk fiber thickness, and fiber alignment.
High-grade astrocytoma with piloid features: MRI findings associated with a novel entity.
Radiol Case Rep
December 2024
Department of Medical Imaging, Hamilton General Hospital, Hamilton, Canada.
Article Synopsis
- A new type of brain tumor called high-grade astrocytoma with piloid features needs special DNA tests to be diagnosed.
- A 34-year-old man had headaches and dizziness, and doctors found the tumor after surgery using DNA analysis.
- The imaging tests showed specific patterns of the tumor that matched the findings in the tissue samples, helping to understand this new type of brain tumor better.
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