91 men with non-gonococcal urethritis (including urethritis due to Chlamydia trachomatis and non-specific urethritis) were treated by a 14-day course of doxycycline hyclate; 75% were considered cured at follow-up on the 10th day and 3-4 months post-treatment. The results show a bettter cure rate (83%) in urethritis due to Chlamydia trachomatis than in non-specific urethritis (64%). A 5-day course of doxycycline hyclate was disappointing and was followed by a very high recurrence rate in both groups. Simultaneous treatment of sex patners is advisable as this appears to lower the recurrence rate in the group of men with chlamydial urethritis.

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