The transforming protein of Kirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.
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http://dx.doi.org/10.1126/science.6287573 | DOI Listing |
IUCrdata
May 2024
Martin-Luther-Universität Halle, Naturwissenschaftliche Fakultät II, Institut für Chemie, Germany.
Transamination of Sn(NMe) with HNMes (Mes is 2,4,6-tri-methyl-phenyl, CH) led to the formation of the title compound, [Sn(CHN)] or Sn(NHMes), which crystallizes in the tetra-gonal space group 2 , with four formula units per unit cell. The mol-ecular structure consists of a central tin(IV) atom, which is surrounded by four NHMes groups. Sn(NHMes) possesses crystallographically imposed symmetry.
View Article and Find Full Text PDFMol Carcinog
October 2019
Division of Microbiology and Infectious Diseases, Shiga University of Medical Science, Shiga, Japan.
Phosphorylation of pyruvate dehydrogenase by pyruvate dehydrogenase kinase 4 (PDK4) 4 inhibits its ability to induce a glycolytic shift. PDK4 expression is frequently upregulated in various cancer tissues, with its elevation being critical for the induction of the Warburg effect. PDK4 is an attractive target for cancer therapy given its effect on shifting glucose metabolism.
View Article and Find Full Text PDFNat Commun
May 2017
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada.
Acta Crystallogr E Crystallogr Commun
October 2015
Department of Chemistry and Research Center for Smart Molecules, Rikkyo University, Nishi-Ikebukuro 3-34-1, Toshima-ku, 171-8501 Tokyo, Japan.
The structure of the title compound, which represents a mixed-valence platinum(II,IV) complex, {[Pt(II)Pt(IV)I2(C2H8N2)4][CH3(CH2)7SO3]4·2H2O} n , has been redetermined in a different space group. In contrast to the previously reported determination in the space group P21 cn [Matsushita & Taira (1999 ▸). Synth.
View Article and Find Full Text PDFInt J Mol Sci
October 2015
Division of Molecular Radiobiology, National Public Health Center-National Research Directorate for Radiobiology and Radiohygiene, Anna 5, Budapest 1221, Hungary.
Tumor protein 53-induced nuclear protein-1 (TP53inp1) is expressed by activation via p53 and p73. The purpose of our study was to investigate the role of TP53inp1 in response of fibroblasts to ionizing radiation. γ-Ray radiation dose-dependently induces the expression of TP53inp1 in human immortalized fibroblast (F11hT) cells.
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