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Benzo [a] pyrene (B[a]P) is a potent mutagen and carcinogen, considered one of the commonest concomitants in the environment. The study aimed to evaluate the effect of catechin hydrate on benzo pyrene-induced kidney toxicity. Thirty-six adult male albino rats were divided into six groups: group I untreated control, group II received 10 mL/kg of corn oil (solvent of benzo [a] pyrene) twice a week, group III received 1 mL/kg 0.

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The malignant transformation of human bronchial epithelial cell 16HBE induced by benzo (a) pyrene metabolite--dihydroxyepoxy benzo pyrene (BPDE) was studied. 16HBE cells were treated several times with BPDE at different concentrations in vitro. The identification on the malignancy of transformed 16HBE cells was investigated.

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