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The and of Vincent van Gogh: neuropeptides of bondedness and loss.
Front Psychol
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, United States.
We introduce two Korean-named yet transcultural feelings, and , to fill gaps in neuroscientific understanding of mammalian bondedness, loss, and aggression. is a visceral sense of connectedness to a person, place, or thing that may arise after proximity, yet does not require intimacy. The brain opioid theory of social attachment (BOTSA) supports the idea that involves increased activity of enkephalins and beta-endorphins.
View Article and Find Full Text PDFDeletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration.
Front Pharmacol
September 2024
Center for Neuroscience, University of California-Davis, Davis, CA, United States.
Article Synopsis
- Opioid drugs activate the µ-opioid receptor, mimicking natural pain-relieving peptides, but their use is limited due to side effects and the risk of opioid use disorder.
- The study examined how different levels of arrestin-3 recruitment to the µ-opioid receptor in mice affected their drug-seeking behavior, revealing that mice without arrestin-3 showed more compulsive tendencies.
- The findings suggest that opioids activating both G proteins and arrestin-3 could lead to decreased risk of abuse, indicating a potential pathway for improving pain management without increasing addiction risk.
Effects of Pain Relief Through Minimal Exercise Intervention in a Rat Model of Neuropathic Pain.
Cureus
June 2024
Physical Therapy, School of Health Sciences, Kagoshima University, Kagoshima, JPN.
We aimed to minimize the frequency of exercise intervention and test the efficacy of pain relief. We also investigated the mechanism of neuropathic pain to determine the best frequency of pain relief for neuropathic pain. The chronic constriction injury (CCI) rat model was randomly divided into three groups: exercise (Ex), No-Ex, and normal.
View Article and Find Full Text PDFCurrent advances in the pain treatment and mechanisms of Traditional Chinese Medicine.
Phytother Res
August 2024
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Traditional Chinese Medicine (TCM), as a unique medical model in China, has been shown to be effective in the treatment of many diseases. It has been proven that TCM can increase the pain threshold, increase the level of endorphins and enkephalins in the body, and reduce the body's response to adverse stimuli. In recent years, TCM scholars have made valuable explorations in the field of pain treatment, using methods such as internal and external application of TCM and acupuncture to carry out research on pain treatment and have achieved more satisfactory results.
View Article and Find Full Text PDFEndogenous opiates and behavior: 2023.
Peptides
September 2024
Department of Psychology and Psychology Doctoral Sub-Program, Queens College and the Graduate Center, City University of New York, USA. Electronic address:
This paper is the forty-sixth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2023 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug and alcohol abuse (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
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