The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE) and unsulfated cholecystokinin (CCK-8-NS) were studied following intraventricular administration on active avoidance and conditioned feeding behaviour of rats. In the CCK-8-NS and CCK-8-SE treated animals the acquisition of active avoidance and conditioned feeding behaviour were considerably impaired compared to the control; furthermore, these peptides caused a facilitated extinction of active avoidance and conditioned feeding behaviour. The data suggest that cholecystokinin octapeptide is capable of modifying the fear and hunger motivated behaviours of rats.
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Article Synopsis
- * LTP was found to decrease levels of pro-inflammatory cytokines and prevent microglial activation, suggesting a protective role against inflammatory damage in the brain following AICH.
- * The research implies that LTP may work through the gut-brain axis by increasing cholecystokinin octapeptide (CCK-8) levels and altering expressions of key proteins in both the brain and intestine, thereby mitigating neuroinflammation.
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