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Feasibility of on-site CT-FFR analysis on cardiac photon-counting CT in evaluation of hemodynamically significant stenosis in comparison to invasive catheter angiography.
Eur J Radiol
January 2025
Department of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:
Objectives: Coronary CT angiography (CCTA) is an excellent tool in ruling out coronary artery disease (CAD) but tends to overestimate especially highly calcified plaques. To reduce diagnostic invasive catheter angiographies (ICA), current guidelines recommend CT-FFR to determine the hemodynamic significance of coronary artery stenosis. Photon-Counting Detector CT (PCCT) revolutionized CCTA and may improve CT-FFR analysis in guiding patients.
View Article and Find Full Text PDFCase-Based Virtual Reality Simulation for Severe Pelvic Trauma Clinical Skill Training in Medical Students: Design and Pilot Study.
JMIR Med Educ
January 2025
Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Teaching severe pelvic trauma poses a significant challenge in orthopedic surgery education due to the necessity of both clinical reasoning and procedural operational skills for mastery. Traditional methods of instruction, including theoretical teaching and mannequin practice, face limitations due to the complexity, the unpredictability of treatment scenarios, the scarcity of typical cases, and the abstract nature of traditional teaching, all of which impede students' knowledge acquisition.
Objective: This study aims to introduce a novel experimental teaching methodology for severe pelvic trauma, integrating virtual reality (VR) technology as a potent adjunct to existing teaching practices.
Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021.
PLoS One
January 2025
Departement of Epidemiology, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
Introduction: Ovarian cancer is one of the most lethal gynecological cancers. Despite diagnosis and treatment advances, survival rates have not increased over the past 32 years. This study estimated and reported the global burden of ovarian cancer during the past 32 years to inform preventative and control strategies.
View Article and Find Full Text PDFImplementation outcomes of 1-3-7 focus investigation for malaria in a low transmission setting in Southern Province, Zambia: A mixed methods study.
PLOS Glob Public Health
January 2025
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Eleven countries have been certified as malaria free since 2016, but none of these are in subSaharan Africa where elimination challenges are unique. The 1-3-7 focus investigation approach is an implementation strategy that requires case reporting, case investigation/classification, and focal classification/response to be completed one, three, and seven days, respectively, after index case diagnosis. Real-time short-messaging-service reports are sent at each step to add accountability and data transparency.
View Article and Find Full Text PDFAt what cycle threshold level are dogs able to detect SARS-CoV-2 in humans?
PLoS One
January 2025
Instituto de Biología, Universidad Nacional Autónoma de México (UNAM), México City, México.
Dogs can discriminate between people infected with SARS-CoV-2 from those uninfected, although their results vary depending on the settings in which they are exposed to infected individuals or samples of urine, sweat or saliva. This variability likely depends on the viral load of infected people, which may be closely associated with physiological changes in infected patients. Determining this viral load is challenging, and a practical approach is to use the cycle threshold (Ct) value of a RT-qPCR test.
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