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Community characteristics and relationship between gut microbiota and intratumoral microbiota in hepatocellular carcinoma.
Front Immunol
January 2025
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Background: The combination of local therapy with lenvatinib and programmed cell death protein-1 (PD-1) inhibitors represents an emerging treatment paradigm for unresectable hepatocellular carcinoma (uHCC). Our study sought to investigate the interrelationship between gut microbiota and intratumoral microbiota in the context of triple therapy, with a view to identifying potential biological markers.
Methods: The gut microbial community profiles of patients with primary untreated hepatocellular carcinoma (HCC) and those treated with local therapy combined with lenvatinib and PD-1 inhibitors were analyzed by 16S rRNA gene amplicon sequencing.
The long-run effect of historical redlining practices on social vulnerability in U.S. cities.
Cities
February 2025
Department of Geography & Environmental Studies, University of New Mexico, Albuquerque, New Mexico, 87131, USA.
Historical redlining practices in the United States date back to the 1930s and have continued to impact cities socially, environmentally, and economically since then. This study explores current social vulnerability inequity among former HOLC (Home Owners' Loan Corporation) neighborhoods with four color-coded grades in 196 U.S.
View Article and Find Full Text PDFDifferences in Ocular Biometry Between Short-Axial and Normal-Axial Eyes in the Elderly Japanese.
Clin Ophthalmol
January 2025
Department of Ophthalmology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan.
Purpose: Among patients with angle-closure glaucoma, it is common to have a short-axial eye, which also makes it difficult to select an appropriate intraocular lens. Previous studies have focused on the ocular biometry of the long-axial eye, whereas only a few reports have focused on the short-axial eye. This study aimed to clarify the characteristics of the short-axial eye on ocular biometry among the elderly Japanese.
View Article and Find Full Text PDFAncestral Sequence Reconstruction and Comprehensive Computational Simulations Unmask an Efficient PET Hydrolase with the Wobbled Catalytic Triad.
ChemSusChem
January 2025
Nanjing Normal University, School of Food Science and Pharmaceutical Engineering, No. 2 Xuelin Road, 210023, Nanjing, CHINA.
Beyond directed evolution, ancestral sequence reconstruction (ASR) has emerged as a powerful strategy for engineering proteins with superior functional properties. Herein, we harnessed ASR to uncover robust PET hydrolase variants, expanding the repertoire of PET-degrading enzymes and providing deeper insights into the underlying mechanisms of PET hydrolysis. As a result, ASR1-PETase, featuring a unique cysteine catalytic site, was discovered.
View Article and Find Full Text PDFComparison of conventional coagulation tests and ROTEM in identifying trauma-induced coagulopathy for massive haemorrhage protocol activation.
Transfus Med
January 2025
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Objectives: Trauma-induced coagulopathy (TIC) can be fatal but preventable if recognised early. With emerging uses of rotational thromboelastometry (ROTEM) to guide transfusions in trauma, patient outcomes with TIC-defined by initial ROTEM and conventional coagulation tests (CCTs) during massive haemorrhage protocol (MHP) activations were evaluated at a primary trauma centre in British Columbia.
Methods: This retrospective observational study included adult trauma patients requiring MHP from June 1, 2020, to May 31, 2022.
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