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(Un)Tying the Knot: Oxidative Stress, Inflammatory Markers, and Lipid Status in Dogs with Hypercortisolism.
Animals (Basel)
December 2024
Department of Pathophysiology, Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Belgrade, Serbia.
The aim of this study was to revisit the complex relationship between inflammation, oxidative stress and lipid metabolism in dogs with hypercortisolism (HC). Fourteen dogs newly diagnosed with HC and an equal number of healthy counterparts of similar age and markers of oxidative stress (AOPP, TBARS, TAC, GSH, PON-1, and UA) and inflammation (NLR, PLR, SII, HPT, CHE, CP, and Hcy) were included in the study. To determine the lipid profiles, cholesterol, and triglyceride levels were measured, and the electrophoretic separation of lipoproteins was performed.
View Article and Find Full Text PDFInitial development of a rapid, portable, stall-side ELISA for the measurement of equine adrenocorticotropic hormone.
J Vet Diagn Invest
September 2024
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Pituitary pars intermedia dysfunction (PPID) is a neurodegenerative disease of senior horses. Loss of dopaminergic inhibition of the melanotropes of the pars intermedia leads to increased concentrations of pro-opiomelanocortin (POMC)-derived peptides. Diagnosis is challenging due to pre-analytical variables, such as sample storage, handling, and time to analysis.
View Article and Find Full Text PDFMetabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control.
Curr Drug Metab
December 2024
Drug Analysis Department, Laboratory of Racing Chemistry, 1731-2 Tsuruta-machi, Utsunomiya, Tochigi, 320-0851, Japan.
Article Synopsis
- The study investigates osilodrostat, a drug for Cushing's disease, and its potential misuse in horse racing due to its anabolic properties, leading to its classification as a banned substance.
- Four thoroughbred horses were given osilodrostat, and extensive screening identified 37 metabolites, with key findings including M1c (a mono-hydroxylated form) and osilodrostat glucuronide, which showed a long detection time in urine.
- For effective doping control, both osilodrostat and M1c should be screened in horse urine samples, and only osilodrostat can be confirmed using a reference material.
Quantification of osilodrostat in horse urine using LC/ESI-HRMS to establish an elimination profile for doping control.
Bioanalysis
October 2024
Drug Analysis Department, Laboratory of Racing Chemistry, 1731-2 Tsuruta-machi, Utsunomiya, Tochigi, 320-0851, Japan.
Article Synopsis
- Osilodrostat, an anabolic agent developed for Cushing's disease, is banned in horses by major equestrian authorities due to its potential misuse in doping.
- Studies established the elimination profiles of osilodrostat and its metabolite M1c in horse urine, using a validated method for accurate detection post-administration.
- Findings indicate hydrolyzed osilodrostat can be detected for up to 72 hours, while both it and M1c can be found in urine samples for up to 2 weeks, leading to recommendations for monitoring both substances for effective doping control.
Ex vivo comparison of one-layer versus two-layer closures in end-to-end anastomoses in normal equine descending colon.
Vet Surg
January 2025
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.
Objective: The aim of the study was to evaluate time to closure, bursting pressures and luminal diameters of a single and double-layer end-to-end anastomoses in normal equine descending colon.
Study Design: Experimental study.
Sample Population: Eight adult horses.
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