Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10(-8) M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluoromelatonin (10(-7) M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10(-5) M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10(-7) M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations.
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