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Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing.
Part Fibre Toxicol
December 2024
Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Article Synopsis
- - The inhalation of respirable crystalline silica, particularly quartz, is linked to serious health issues like lung inflammation, fibrosis, cancer, and autoimmune diseases, with nearly free silanols (NFS) from fractured quartz being key players in this toxicity.
- - Experiments on mice showed that exposure to NFS-rich quartz caused significant acute and long-term inflammatory responses, fibrosis, cancer, and autoimmune signs, while NFS-poor quartz showed no such effects.
- - The study highlights that NFS-rich quartz specifically triggers harmful biological responses, including increased pro-inflammatory cytokines, lung fibrosis markers, tumors, and autoantibodies, underscoring its health risks compared to less reactive quartz forms.
IGF2BP3 overexpression predicts poor prognosis and correlates with immune infiltration in bladder cancer.
BMC Cancer
February 2023
Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi, China.
Background: IGF2BP3 expression is associated with poor prognosis in cancers of multiple tissue origins. However, the precise mechanism of its co-carcinogenic action in bladder cancer is unknown.
Methods: We aimed to demonstrate the relationship between IGF2BP3 expression and pan-cancer using The Cancer Genome Atlas (TCGA) database.
An overview of the biological effects of extremely low frequency electromagnetic fields combined with ionizing radiation.
Prog Biophys Mol Biol
August 2022
Laboratory of Biophysics and Molecular Biology, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
By growing the electrical power networks and electronic devices, electromagnetic fields (EMF) have become an inseparable part of the modern world. Considering the inevitable exposure to a various range of EMFs, especially at extremely low frequencies (ELF-EMF), investigating the biological effects of ELF-EMFs on biological systems became a global issue. The possible adverse consequences of these exposures were studied, along with their potential therapeutic capabilities.
View Article and Find Full Text PDFPlacental levels of polycyclic aromatic hydrocarbons (PAHs) and their association with birth weight of infants.
Drug Chem Toxicol
March 2022
Department of Chemistry, Dr. B. R. Ambedkar University, Agra, India.
As an alarming group of pollutants, polycyclic aromatic hydrocarbons (PAHs) gather much public health concern not only because of their carcinogenic or co-carcinogenic risk but also by interfering with hormone systems or by causing oxidative damage, henceforth liable to toxic actions on reproduction. Accordingly, the present study was aimed to explore the association between exposure to PAHs by evaluating their placental levels and infant birth weight among 110 healthy and nonsmoking pregnant women. Placental tissue samples were collected instantly after delivery and were analyzed for the presence of sixteen Environmental Protection Agency (EPA) listed PAHs with the help of Gas chromatography equipped with flame ionization detector (GC-FID).
View Article and Find Full Text PDFeIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine.
Toxicology
May 2019
School of Public Health, Nanchang University, 461 Ba Yi Avenue, Nanchang, Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, 461 Ba Yi Avenue, Nanchang, Jiangxi, 330006, PR China. Electronic address:
Tobacco smoke is known as a cofactor in the development of cervical precancer and cancer caused by human papillomavirus (HPV). The main component in cigarette smoke, nicotine, can be concentrated more strongly in cervical mucus than in blood and it has been implicated as a cocarcinogen that promotes a serial of cancers development through multiple prosurvival pathways. Although the mechanisms of nicotine-induced cell proliferation have been well studied in some epithelial cells, the molecular mechanism of its action in cervical epithelial cells is still unclear.
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