AI Article Synopsis
- The study examines 11 cases of congenital virilizing adrenal hyperplasia, highlighting significant virilization of external genitalia in girls.
- Arterial hypertension typically develops later in life, with high levels of plasma androgens and desoxycortisol, while plasma 17-hydroxyprogesterone may appear only slightly elevated, which can be misleading.
- Treatment with hydrocortisone yields good results, but long-term risks for treated children include chronic hypertension in both genders, earlier puberty in girls, and pubertal gynecomastia in boys.
Article Abstract
Eleven cases of congenital virilizing adrenal hyperplasia are studied. This study leads to point out some peculiar characteristics: virilization of external genitalia in girls is most usually important; arterial hypertension is delayed, usually after some years; plasma androgens and desoxycortisol are highly elevated; plasma 17-hydroxyprogesterone is slightly elevated and this may be misleading; good results of treatment which must preferably use hydrocortisone since plasma cortisol is sometimes low; long-term risks in treated children include chronic hypertension in both sexes, advanced puberty in girls and pubertal gynecomastia in boys.
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