A procedure for the quantitation and detection of cannabinoids in biological fluids (plasma and urine) is described. This method is based on isotopic derivatization and double labeling. delta 9-Tetrahydrocannabinol and two of its metabolites (11-hydroxy-delta 9-THC and 8-beta-hydroxy-delta 9-THC) can be detected and measured in plasma or urine. The use of TLC enables specific separation of cannabinoids. The sensitivity of detection (4 ng/mL) is compatible with cannabinoid kinetics. The procedure can be applied to routine measurements and pharmacokinetic studies.
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