AI Article Synopsis
- The study involved exposing rats to a combination of carbon monoxide and a superoxide dismutase inhibitor, diethyldithiocarbamate, resulting in a high mortality rate among the treated rats.
- Out of twenty-three rats exposed to both treatments, sixteen died, indicating a significant impact of the combined exposure.
- In contrast, no deaths occurred in the control groups, including rats exposed to carbon monoxide without the inhibitor or those injected with the inhibitor but not exposed to carbon monoxide.
Article Abstract
Simultaneous exposure of rats to carbon monoxide (COHb 60%) and diethyldithiocarbamate (i.p. 0.5 g/kg), a superoxide dismutase inhibitor, for 2.5 h resulted in a death of sixteen out of twenty-three rats. No rats treated with saline and exposed to CO died (0/26). There were no fatalities among the group of rats injected with the diethyldithiocarbamate solution and exposed to ambient air (0/16).
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