Morphine was shown to promote dopamine (DA) synthesis and release in mouse striatum, but mice rendered tolerant and dependent on ethanol were found to be less responsive to morphine's effects on striatal DA metabolism than control animals. Ethanol feeding also produced a change in the affinity of striatal "opiate" receptors for [3H]dihydromorphine, and these ethanol-induced receptor changes may be responsible for the altered biological effect of morphine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1471-4159.1981.tb00487.x | DOI Listing |
Publication Analysis
Top Keywords
ethanol alters
4
alters kinetic
4
kinetic characteristics
4
characteristics function
4
function striatal
4
striatal morphine
4
morphine receptors
4
receptors morphine
4
morphine promote
4
promote dopamine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!