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Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?
Biogerontology
January 2025
UCIBIO-Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116, Gandra, Portugal.
Sarcopenia and cancer cachexia are two life-threatening conditions often misdiagnosed. The skeletal muscle is one of the organs most adversely affected by these conditions, culminating in poor quality of life and premature mortality. In addition, it has been suggested that chemotherapeutic agents exacerbate cancer cachexia, as is the case of doxorubicin.
View Article and Find Full Text PDFRisk Factors for 30-Day Postoperative Infection in Pediatric Ventricular Shunts for Hydrocephalus.
World Neurosurg
January 2025
Division of Neurosurgery, University of Alberta, Edmonton, AB, Canada. Electronic address:
Background: Ventricular shunt infections lead to significant morbidity and mortality. This study aimed to identify risk factors for 30-day postoperative infection outcomes of ventricular shunts for pediatric hydrocephalus.
Methods: This was a retrospective cohort study using the National Surgical Quality Improvement Program (NSQIP) Pediatric database for years 2016-2021.
Perioperative anaphylaxis manifesting as cardiac arrest during cardiac surgery.
Allergy Asthma Proc
January 2025
Perioperative anaphylaxis is a serious entity with high morbidity and mortality. Perioperative anaphylaxis can be caused by any of the multitude of medications and substances used in anesthesia and surgery, and the most common causes include neuromuscular blocking agents, antibiotics, antiseptics, latex, and dyes. The differential diagnosis of perioperative anaphylaxis is wide from both an immunologic and a nonimmunologic standpoint.
View Article and Find Full Text PDFOccupational anaphylaxis: A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI).
Allergol Select
November 2024
Department of Dermatology and Allergy Biederstein, School of Medicine and Health, Technical University of Munich TUM).
Background: Anaphylaxis is a systemic allergic reaction that is potentially life-threatening. Occupational anaphylaxis is an anaphylaxis that occurs in an occupational context. In this position paper, we propose diagnostic criteria for occupational anaphylaxis and provide an overview of the current state of knowledge in terms of prevalence, triggers, prevention, and management.
View Article and Find Full Text PDFAntibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses.
Nat Biomed Eng
November 2024
Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke Cancer Research Institute, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Article Synopsis
- Optimizing oncolytic viruses for cancer treatment involves removing harmful genes and adding new ones to improve their ability to replicate and stimulate immune responses.
- The complex nature of viral genomes and the difficulty of creating modified viruses have slowed progress in developing these therapies.
- Researchers used a novel strategy involving antibiotics, transposon systems, and advanced sequencing to efficiently engineer safer and more effective oncolytic viruses by identifying useful genetic changes.
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