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Radiosynthesis of [18F]-flumazenil Using an Isotopic Approach.
Indian J Nucl Med
November 2024
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Background: Fluorine-18 (F) flumazenil (FMZ) has been synthesized using various precursors, and its role has been explored in imaging Gamma-aminobutyric acid-A receptors.
Aim And Objective: The main objective was to synthesize (F) FMZ using isotopic substitution.
Materials And Methods: Around 18 ± 2 GBq was added to the module, dried, and radiolabeling was standardized with 3.
Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
Gut Microbes
December 2024
Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Article Synopsis
- Autism spectrum disorder (ASD) currently has no effective diagnostic or treatment methods, but disruptions in gut microbiota have been linked to ASD, leading to research into probiotics and dietary changes as potential therapies.
- A study compared the gut microbiomes of children with ASD to typically developing children, identifying unique dysbiosis patterns and assessing the impact of a combined probiotic (Probio-M8) and medium-carbohydrate diet over three months.
- Results indicated that the intervention significantly improved autism symptoms and gastrointestinal health, with corresponding positive changes in gut bacteria and associated metabolites, suggesting that this approach could be a valuable addition to ASD treatment options.
Flavonoids from mulberry leaves exhibit sleep-improving effects via regulating GABA and 5-HT receptors.
J Ethnopharmacol
January 2025
School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China; Food Laboratory of Zhongyuan, Zhengzhou University, Luohe, Henan, 462300, China. Electronic address:
Ethnopharmacological Relevance: Mulberry leaf (Folium Mori) is a dried leaf of the dicotyledonous mulberry tree and is a homologous food and medicine. Treating insomnia with it is a common practice in traditional Chinese medicine. But still, its potential sleep-improving mechanism remains to be elucidated.
View Article and Find Full Text PDFEffects of Microbial Proteins on Qingzhuan Tea Sensory Quality during Pile Fermentation.
J Agric Food Chem
September 2024
Fruit and Tea Research Institute, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
To determine the effects of microbial proteins on Qingzhuan tea sensory quality during tea pile fermentation, tea leaf metabolomic and microorganism proteomic analyses were performed. In total, 1835 differential metabolites and 443 differentially expressed proteins of the microorganisms were identified. Correlation analysis between metabolomics and proteomics data revealed that the levels of microbial proteins EG II and CBH I cellulase may play important roles in cell wall construction and permeability, which were crucial for the interaction between tea leaves and microorganisms.
View Article and Find Full Text PDFSleep-improving effect and the potential mechanism of Morus alba L. on mice.
Fitoterapia
December 2024
School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; Food Laboratory of Zhongyuan, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address:
As insufficient sleep has become a widespread concern in modern society, potential sleep-improving effect of mulberry (Morus alba L.) leaf ethanol extract (MLE) and the related mechanism were investigated in the present study. According to the results, MLE could significantly shorten sleep latency by 33 %, extend sleep duration by 56 % and increase sleep ratio of mice through increasing 5-HT and GABA release in serum, hypothalamus and hippocampus.
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