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PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth.
Int J Mol Sci
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Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Genetic abnormalities of the parathyroid hormone 1 receptor (PTH1R) lead to profound craniomaxillofacial bone and dentition defects on account of inappropriate tissue metabolism and cellular differentiation. The coordinated activity of differentiation and viability in bone cells is indispensable for bone metabolism. Recent research demonstrates mesenchymal progenitors are responsive to PTH1R signaling for osteogenic differentiation, whereas the effect of PTH1R on cellular survival remains incompletely understood.
View Article and Find Full Text PDFPersonal Genetic-Hypertension Odyssey From Phenotypes to Genotypes and Targets.
Hypertension
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Experimental and Clinical Research Center, a cooperation between the Max-Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Berlin, Germany.
Hypertension requires increased systemic vascular resistance. Thus far, Mendelian hypertension-related genes are related to salt retention, an indirect regulatory effect. With the identification of mutated, overactive, PDE3A (phosphodiesterase 3A), we have uncovered a more direct vasoconstrictive mechanism.
View Article and Find Full Text PDFMechanoinduction of PTHrP/cAMP-signaling governs proteoglycan production in mesenchymal stromal cell-derived neocartilage.
J Cell Physiol
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Department of Orthopaedics, Experimental Orthopaedics, Research Centre for Molecular and Regenerative Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.
Abnormal mechanical loading is one of the major risk factors for articular cartilage degeneration. Engineered mesenchymal stromal cell (MSC)-derived cartilage holds great promise for cell-based cartilage repair. However, physiological loading protocols were shown to reduce matrix synthesis of MSC-derived neocartilage in vitro and the regulators of this undesired mechanoresponse remain poorly understood.
View Article and Find Full Text PDFInduced pluripotent stem cells derived renal tubular cells from a patient with pseudohypoparathyroidism and its response to parathyroid hormone stimulation.
Mol Biol Rep
July 2024
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-chou, Itabashi-ku, Tokyo, 173-8610, Japan.
Article Synopsis
- The study focuses on creating induced pluripotent stem cells (iPSCs) from patients with genetic diseases, specifically Pseudohypoparathyroidism (PHP), to better understand rare renal tubular diseases.
- Researchers extracted iPSCs from two patients' peripheral blood cells and differentiated them into renal tubular cells to analyze their response to parathyroid hormone (PTH).
- The results showed that the tubular cells from healthy control subjects responded predictably to PTH, while those from PHP patients displayed inconsistent responses, highlighting the significance of using disease-specific iPSCs for studying disease mechanisms and potential treatments.
Aim: To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).
Materials And Methods: The study included 173 women with RA (age 61.0 [56.
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