Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Synthesis and evaluation of a multifunctional probe with a high affinity for prostate-specific membrane antigen (PSMA) and bone.
Nucl Med Biol
December 2022
Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-1192, Japan; Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan. Electronic address:
Prostate cancer frequently metastasizes to the bone. Because patients with bone metastases suffer from skeletal-related events, the diagnosis and treatment of bone metastases in the early stage are important. In this study, to improve the sensitivity of detecting bone metastases in patients with prostate cancer, we designed, synthesized, and evaluated a multifunctional radiotracer, [Ga]Ga-D-PSMA-617 ([Ga]3), with an undeca-aspartic acid as a bone-seeking moiety between [Ga]Ga-DOTA and a prostate-specific membrane antigen (PSMA) ligand based on the lysine-urea-glutamate motif.
View Article and Find Full Text PDFTracking Uptake and Metabolism of Xenometallomycins Using a Multi-Isotope Tagging Strategy.
ACS Infect Dis
April 2022
Department of Chemistry, Stony Brook University, 100 Nicolls Road, Stony Brook, New York 11794, United States.
Synthetic and naturally occurring siderophores and their conjugates provide access to the bacterial cytoplasm via active membrane transport. Previously, we displaced iron with the radioactive isotope Ga to quantify and track in vitro and in vivo uptake and distribution of siderophore Trojan Horse antibiotic conjugates. Here, we introduce a multi-isotope tagging strategy to individually elucidate the fate of metal cargo and the ligand construct with radioisotopes Ga and I.
View Article and Find Full Text PDFDevelopment of novel Ga-labeled pyridyl benzofuran derivatives as islet amyloid imaging probes.
Nucl Med Biol
March 2022
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:
Introduction: Type 2 diabetes mellitus (T2DM) accounts for the majority of diabetes mellitus cases, and β-cell function and mass may be involved in its pathophysiology. The deposition of islet amyloid in pancreas islets is one of the mechanisms of progression of T2DM. Therefore, the development of imaging techniques for islet amyloid deposition contributes to the early-phase diagnosis and elucidation of the pathogenic mechanism of T2DM.
View Article and Find Full Text PDFDevelopment of modified polymer dot as stimuli-sensitive and Ga radio-carrier, for investigation of in vitro drug delivery, in vivo imaging and drug release kinetic.
J Pharm Biomed Anal
September 2021
Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran; D-8 International University, Hamedan, Iran.
A polymer dot modified histidine-functionalized graphene quantum dot carrier, PD@His.GQD, was synthesized to investigate the in vitro sunitinib (STB) deliveryvia luminescence spectrometer. The carrier's synthesis, with an average size of 34 nm, was proved by Fourier transform infrared (FTIR), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS) analyses.
View Article and Find Full Text PDFRadiotracers for Bone Marrow Infection Imaging.
Molecules
May 2021
Department of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark.
Introduction: Radiotracers are widely used in medical imaging, using techniques of gamma-camera imaging (scintigraphy and SPECT) or positron emission tomography (PET). In bone marrow infection, there is no single routine test available that can detect infection with sufficiently high diagnostic accuracy. Here, we review radiotracers used for imaging of bone marrow infection, also known as osteomyelitis, with a focus on why these molecules are relevant for the task, based on their physiological uptake mechanisms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!