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Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations.
Neurology
February 2025
Department of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Background And Objectives: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme that regulates folate and homocysteine metabolism. Genetic variation in has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking. We thus aimed to investigate the effect of genetically predicted MTHFR activity on risk of ischemic stroke (IS) and its main subtypes using a multiancestry Mendelian randomization (MR) approach.
View Article and Find Full Text PDFDivergent Cotton leaf curl Multan betasatellite and three different alphasatellite species associated with cotton leaf curl disease outbreak in Northwest India.
PLoS One
January 2025
Entomology & Biothreat Management Division, Defense Research Laboratory (DRL-DRDO), Tezpur, Assam, India.
Cotton leaf curl disease (CLCuD) is a major constraint for production of cotton (Gossypium sp.) in Northwest India. CLCuD is caused by a monopartite, circular ssDNA virus belonging to the genus Begomovirus in association with betasatellites and alphasatellites, and ttransmitted by a whitefly vector (Bemisia tabaci).
View Article and Find Full Text PDFIdentifying genetic susceptibility loci associated with human coronary artery disease.
PLoS One
January 2025
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Coronary artery disease (CAD) is a multigenic condition influenced by both nature and nurture (60% to 40%). Prognosis of CAD is based on familial patterns. This study examined and analyzed the susceptibility of CAD to genetic variants in various Pakistani families.
View Article and Find Full Text PDFpmiRScan: a LightGBM based method for prediction of animal pre-miRNAs.
Funct Integr Genomics
January 2025
Computational Structural Biology Lab, Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
MicroRNAs (miRNA) are categorized as short endogenous non-coding RNAs, which have a significant role in post-transcriptional gene regulation. Identifying new animal precursor miRNA (pre-miRNA) and miRNA is crucial to understand the role of miRNAs in various biological processes including the development of diseases. The present study focuses on the development of a Light Gradient Boost (LGB) based method for the classification of animal pre-miRNAs using various sequence and secondary structural features.
View Article and Find Full Text PDFAlcohol Use Disorder Polygenic Score Compared With Family History and ADH1B.
JAMA Netw Open
December 2024
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis.
Importance: Identification of individuals at high risk of alcohol use disorder (AUD) and subsequent application of prevention and intervention programs has been reported to decrease the incidence of AUD. The polygenic score (PGS), which measures an individual's genetic liability to a disease, can potentially be used to evaluate AUD risk.
Objective: To assess the estimability and generalizability of the PGS, compared with family history and ADH1B, in evaluating the risk of AUD among populations of European ancestry.
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