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Alzheimers Dement
December 2024
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
Background: Regional distribution of neurofibrillary tangles consisting of hyperphosphorylated tau correlates strongly with the progression of Alzheimer's disease (AD). Misfolded proteopathic tau templates the conversion of naive tau into a pathological state in a prion-like fashion, which underlies the spreading of tau pathology in the brain. Whether hyperphosphorylation triggers tau aggregation or hyperphosphorylation occurs after aggregation is under much debate.
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Alzheimers Dement
December 2024
University of Kentucky College of Medicine, Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: Our lab recently developed 2 mouse monoclonal antibodies that preferentially react with "distressed astrocytes". One monoclonal, 26A6, was found to react preferentially with a form of the Ca2+/calmodulin-dependent protein phosphatase, calcineurin (CN), that has been cleaved by calpain, to generate a 48 kDa CN fragment (∆CN). We recently published a characterization of this antibody.
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Alzheimers Dement
December 2024
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Cardiometabolic disorders represent a pressing public health challenge and confer heightened susceptibility to age-related cognitive decline, including increased risk of developing Alzheimer's disease (AD). There is a strong genetic component underlying risks for these conditions, and human Genome-Wide Association Studies (GWAS) have associated the PPP1R3B genetic locus with both cardiometabolic dysfunction and AD. PPP1R3B protein is primarily expressed in liver hepatocytes, regulating liver glycogen metabolism.
View Article and Find Full Text PDFProtein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target.
Theranostics
January 2025
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The tumor microenvironment (TME) is involved in cancer initiation and progression. With advances in the TME field, numerous therapeutic approaches, such as antiangiogenic treatment and immune checkpoint inhibitors, have been inspired and developed. Nevertheless, the sophisticated regulatory effects on the biological balance of the TME remain unclear.
View Article and Find Full Text PDFThermogenic preworkout supplement induces alveolar bone loss in a rat model of tooth movement via RANK/RANKL/OPG pathway.
Braz Oral Res
January 2025
Universidade Federal do Rio Grande do Norte - UFRN, Graduate Program in Dental Sciences, Department of Dentistry, Natal, Brazil.
The aim of this study was to investigate the effect of thermogenic supplementation on the bone tissue of rats subjected to orthodontic movement. A total of 38 male Wistar rats underwent orthodontic movement of the left permanent maxillary first molars for 21 days. The rats were assigned to three groups: Control group: water; Thermogenic 1: C4 Beta Pump thermogenic; or Thermogenic 2: PRE-HD/Pre-workout.
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