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Symptomatic central nervous system tuberculosis and human herpesvirus-6 coinfection with associated hydrocephalus managed with endoscopic third ventriculostomy: A case report and review of human herpesvirus-6 neuropathology.
Surg Neurol Int
August 2024
Division of Pediatric Neurosurgery, Children's Hospital Orange County, Orange, California, United States.
Article Synopsis
- Human herpesvirus 6 (HHV-6) is a common childhood virus that usually causes mild febrile illness but has been linked to more severe conditions like meningoencephalitis in some cases, particularly in those with weakened immune systems.
- A case study details the treatment of an 18-month-old girl who presented with symptoms suggesting meningitis, leading to a diagnosis of HHV-6 after extensive testing and amid concerns for CNS tuberculosis.
- Initially considered incidental, the initiation of antiviral therapy coincided with the child’s clinical improvement, suggesting HHV-6 may have played a more significant role in her condition than previously thought.
A Classic Presentation of Roseola Infantum.
Cureus
January 2024
Family Medicine, Louisiana State University Health Sciences Center, Alexandria, USA.
Article Synopsis
- Roseola is a common childhood viral infection that typically affects infants and toddlers under three years old.
- It starts with a sudden high fever, followed by a distinctive rash that begins in the center of the body and spreads outward once the fever resolves.
- The report discusses an 18-month-old child to illustrate the usual symptoms and progression of this generally mild illness.
How to differentiate skin rash in covid, mononucleosis, chickenpox, sixth disease and measles.
Curr Opin Infect Dis
April 2023
Institute of Dermatology, 'Santa Maria della Misericordia' University Hospital, Udine, Italy.
Article Synopsis
- The review focuses on skin rashes associated with COVID-19, which often resemble other infectious dermatoses like chickenpox and measles, leading to potential misdiagnoses.
- It summarizes clinical patterns of COVID-19 rashes, specifically maculopapular and vesicular types, highlighting key differences from other viral skin eruptions.
- Recognizing these unique features can aid clinicians in accurately identifying COVID-19-related skin issues for more effective management of the infection.
Early Phase Increase in Serum TIMP-1 in Patients with Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion.
Children (Basel)
December 2022
Life Science Research Center, Nagano Children's Hospital, 3100 Toyoshina, Azumino 399-8288, Japan.
Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most frequent subtype of acute encephalopathy syndrome among Japanese children. Exanthem subitum is the most common causative infectious disease of AESD. We herein retrospectively analyzed serum and cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor matrix metalloproteinase-1 (TIMP-1), and seven cytokines in patients with AESD or prolonged febrile seizure (FS) to assess the pathophysiology of AESD and detect biomarkers for diagnosing AESD in the early phase.
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