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Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers.
J Clin Psychopharmacol
August 2019
Department of Psychiatry, University Hospital Brno, Faculty of Medicine Masaryk University, Brno, Czech Republic.
Background: Lithium in the form of lithium carbonate (Li2CO3) has become one of the most effective and widely prescribed drugs for mood stabilization. However, lithium has adverse effects on renal tubular functions, such as decreased concentrating function of the kidneys, and even occasional symptoms of nephrogenous diabetes insipidus occur with additional evidence of glomerular disruption in lithium-treated patients.
Methods: We assessed the kidney function of patients with bipolar disorder who are under long-term lithium treatment using novel markers of kidney damage such as plasma neutrophil gelatinase-associated lipocalin, cystatin C, albuminuria, estimated glomerular filtration rate, Chronic Kidney Disease-Epidemiology Investigation using creatinine and cystatin C, and serum and urinary osmolality, and compared the results with those of age-matched patients with bipolar disorder not treated with lithium.
Genetics and epigenetics of parathyroid hormone resistance.
Endocr Dev
August 2013
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass., USA.
End-organ resistance to the actions of parathyroid hormone (PTH) is defined as pseudohypoparathyroidism (PHP). Described originally by Fuller Albright and his colleagues in early 1940s, this rare genetic disease is subclassified into two types according to the nephrogenous response to the administration of biologically active PTH. In type I, the PTH-induced urinary excretion of both phosphate and cyclic AMP (cAMP) is blunted.
View Article and Find Full Text PDFAdult onset pseudohypoparathyroidism type-1b with normal phosphaturic response to exogenous parathyroid hormone.
Indian J Endocrinol Metab
October 2011
Department of Endocrinology, Army Hospital (Research and Referral), Delhi Cantt, India.
Pseudohypoparathyroidism type-1b is a hereditary disorder of clinical hypoparathyroidism without AHO phenotype, characterized by blunted nephrogenous cyclic-AMP (cAMP) response to exogenous parathyroid hormone (PTH). Here we report a young adult presenting with hypocalcemic tetany with raised PTH levels. His urinary cAMP response to exogenous PTH (recombinant 1-34) was blunted; however, phosphaturic response was normal.
View Article and Find Full Text PDFMeat and soy protein affect calcium homeostasis in healthy women.
J Nutr
July 2006
Yale New Haven Hospital, New Haven, CT, USA.
We showed that increasing dietary protein from omnivorous sources increases intestinal calcium absorption and urinary calcium, whereas a low-protein diet decreases calcium absorption and lowers urinary calcium. To assess the effect of soy protein on this relation, we substituted soy for meat in high- and low-protein diets fed to healthy women. The study consisted of a 2-wk adjustment period followed by a 4-d experimental period in which 20 healthy women consumed, in random order, the following 4 diets: high-protein soy-based, low-protein soy-based, high-protein meat-based, low-protein meat-based.
View Article and Find Full Text PDFReelevation of parathyroid hormone level after parathyroidectomy in patients with primary hyperparathyroidism: importance of decreased renal parathyroid hormone sensitivity.
Surgery
April 2005
Department of Surgery, Noguchi Thyroid Clinic and Hospital Foundation, 6-33 Noguchi-Nakamachi, Beppu Oita 874-0932, Japan.
Background: We hypothesized that impaired peripheral sensitivity to parathyroid hormone (PTH) may play a role in reelevation of PTH after successful operation for primary hyperparathyroidism (pHPT).
Methods: Factors affecting reelevation of PTH were determined in 90 patients who underwent parathyroidectomy for pHPT. PTH/nephrogenous cyclic adenosine monophosphate ratio, as an index of renal resistance to PTH, was examined in relation to factors shown to influence reelevation of PTH.
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