A new case of IgM myeloma in a 47-year-old man is reported. Multiple myeloma was diagnosed by serum electrophoresis and immunoelectrophoresis, marrow plasmocytosis and typical skeletal changes by X - Ray the synthesis of the M - component was demonstrated in the plasma cells of the bone marrow by direct immunofluorescence study. A review of literature was done and relation between macroglobulinemia of Waldenström and IgM myeloma was discussed.
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