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Vasorelaxant effect of fennel seeds (Foeniculum vulgare Mill) extracts on rat mesenteric arteries: Assessment of phytochemical profiling and antioxidant potential.
Fitoterapia
December 2024
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health. Faculty of Sciences, Mohammed First University, Oujda, BP-717, 60000 Oujda, Morocco. Electronic address:
Ethnopharmacological Relevance: Hypertension is a serious health problems and a leading cause of adult mortality worldwide. Foeniculum. vulgare Mill, a plant traditionally used for various ailments, including cardiovascular disorders such as hypertension.
View Article and Find Full Text PDFExploring the relaxation effects of Coptis chinensis and berberine on the lower esophageal sphincter: potential strategies for LES motility disorders.
BMC Complement Med Ther
December 2024
Department of Pediatrics, E-Da Hospital, I-Shou University, No. 1, Yi-Da Road, Yan-Chao District, Kaohsiung City, 82445, Taiwan, R.O.C..
Article Synopsis
- Esophageal achalasia is a condition that affects the lower esophageal sphincter (LES), leading to symptoms like difficulty swallowing, chest pain, and weight loss, with traditional treatments providing limited relief.
- This study investigates the effectiveness of Traditional Chinese Medicine, specifically Coptis chinensis and its active component berberine, in promoting LES relaxation as a potential alternative treatment.
- Results indicate that both C. chinensis extract and berberine significantly relax the LES by activating potassium channels, suggesting further research is warranted for their therapeutic use in esophageal disorders like achalasia.
Potassium channels mediate nitric oxide-induced vasorelaxation in arteries supplying colon cancer.
Prostaglandins Other Lipid Mediat
December 2024
Department of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq; Department of Biology, College of Science, University of Nawroz, Duhok, Kurdistan Region, Iraq.
Introduction: Aberrant vascular function and cancer growth are closely related, with nitric oxide (NO) being a key factor in vascular tone regulation. This study provides Novel insights into the distinctive mechanisms underlying cancer-associated vascular dysfunction by investigating the involvement of potassium (K) channels in NO-mediated vasorelaxation within arteries supplying colon cancer.
Methods: Arterial segments from colon cancer patients were isolated and sectioned into rings, these rings were mounted in an organ bath filled with Krebs' solution and maintained at 37°C.
Enhancing water desalination efficiency through integrated photovoltaic thermal systems with phase change materials.
J Environ Manage
December 2024
Mechanical Engineering Department, Jordan University of Science and Technology (JUST), IRBID, 22110, Jordan.
This study investigates the effectiveness of chemically modified composite phase change materials in photovoltaic thermal solar energy systems and hybrid desalination systems in two municipalities, comparing their efficacy using different draw solutions for thorough comparison. The effect of non-composite Paraffin PCMs, Paraffin/CNTs Composite PCMs, and Nitrogen-doped graphene Composite PCMs on system efficiency over 96 h is investigated. The simulation under natural conditions looks at two scenarios: brackish water desalination in Irbid with tetraethylammonium bromide and seawater desalination in Aqaba with sodium chloride as a draw solution.
View Article and Find Full Text PDFNitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats.
Molecules
November 2024
Laboratory of Cardiometabolic Pharmacology, Postgraduate Program in Pharmacology (UFPR), Federal University of Paraná, Curitiba 81531-980, PR, Brazil.
Article Synopsis
- Apigenin, a flavonoid thought to benefit cardiovascular health, was studied for its effects on vascular function in Spontaneously Hypertensive Rats (SHRs) to understand its mechanisms of action.
- Vascular beds from SHRs were tested with varying doses of apigenin, showing that its ability to lower blood pressure depended on the presence of endothelial cells and was significantly reduced by inhibitors of nitric oxide and potassium channels.
- The research concluded that apigenin causes vasodilation primarily through endothelial nitric oxide and calcium-activated potassium channels, suggesting its potential for therapeutic use in cardiovascular diseases and the need for more clinical studies.
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