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Impact of the COVID-19 pandemic on acute cardiology and neurology services in a secondary peripheral hospital.
Sci Rep
November 2024
Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Article Synopsis
- A study in an Israeli peripheral hospital examined the effects of the COVID-19 pandemic on the management and outcomes of Cerebral Vascular Accidents (CVA) and ST-elevation myocardial infarctions (STEMI) by comparing patient data before and during the pandemic.
- Findings indicated that while the time from arrival to imaging for CVA patients increased, the overall outcomes for CVA remained stable, and even improved for STEMI patients, who experienced shorter intervention times and reduced hospital stays.
- The mortality rates for both conditions did not significantly change, and further interviews with medical staff are being conducted to understand how quality of care was preserved throughout the challenges posed by the pandemic.
ST2 strains associated with bloodstream infections contain a unique mobile genetic element encoding a plasmin inhibitor.
mBio
December 2024
Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology (IBT), Texas A&M Health Science Center, Houston, Texas, USA.
Unlabelled: , a common commensal bacterium, is a leading cause of nosocomial catheter-associated bloodstream infections. sequence type 2 (ST2) is specifically recognized globally for causing invasive disease. In this study, we identified a novel putative integrated conjugative element, pICE-Sepi-ST2, unique to the genomes of ST2.
View Article and Find Full Text PDFThe Feasibility of Thrombolysis Followed with Ultrasound-Guided Percutaneous Transluminal Balloon Angioplasty in Acutely and Sub-Acutely Thrombosed Arteriovenous Fistulas.
Iran J Kidney Dis
October 2024
Department of Nephrology, The Second Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification in Hunan, 139 Renmin Road, Changsha, Hunan 410011, People's Republic of China.
Introduction: Prompt resolution of arteriovenous fistula (AVF) thrombosis is essential to minimize the need for temporary dialysis catheters. Identifying the ideal timing for the management of thrombosed arteriovenous fistula (AVF) is an area that has not been thoroughly explored. Herein, we examined a local infusion of urokinase for thrombolysis followed by ultrasound-guided percutaneous transluminal balloon angioplasty (PTA) in acute and subacute AVF thromboses.
View Article and Find Full Text PDFHypermethylation and suppression of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis.
Mol Ther
January 2025
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address:
Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in renal fibrosis. Here, we report the regulation of microRNA219a-2 by DNA methylation in fibrotic kidneys, unveiling the crosstalk between these epigenetic mechanisms. Through genome-wide DNA methylation analysis and pyrosequencing, we detected the hypermethylation of microRNA219a-2 in renal fibrosis induced by unilateral ureteral obstruction (UUO) or renal ischemia/reperfusion, which was accompanied by a significant decrease in microRNA-219a-5p expression.
View Article and Find Full Text PDFAnti-angiogenic activity of a novel angiostatin-like plasminogen fragment produced by a bacterial metalloproteinase.
Heliyon
August 2024
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo, 183-8509, Japan.
Tumor growth depends on angiogenesis, a process by which new blood vessel are formed from pre-existing normal blood vessels. Proteolytic fragments of plasminogen, containing varying numbers of plasminogen kringle domains, collectively known as angiostatin, are a naturally occurring inhibitor of angiogenesis and inhibit tumor growth. We have developed an "affinity-capture reactor" that enables a single-step method for the production/purification of an angiostatin-like plasminogen fragment from human plasma using an immobilized bacterial metalloproteinase.
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