AI Article Synopsis
- The average platelet cAMP level in healthy pregnant women is 8.2 pmol cAMP/10(9) platelets.
- In patients with premature labor, short-term treatment with fenoterol increased cAMP levels, while long-term use decreased them.
- Caution is advised with fenoterol due to potential increased platelet aggregation, which could raise the risk of blood clots and negatively affect placental blood flow during prolonged treatment.
Article Abstract
The mean platelet cyclic AMP (cAMP) value in normal pregnant women between 20 and 37 weeks of gestation was 8.2 +/- 0.4 (SEM) pmol cAMP/10(9) platelets (n = 100). From 35 patients with premature labor, 81 blood samples were obtained from measurement of the platelet cAMP before, during and after treatment with fenoterol/verapamil. During the first 4 days of therapy there was an increase of cAMP (p < 0.005); with long-term therapy the blood platelet cAMP was decreased (p < 0.005). Because platelet aggregation has a negative correlation with platelet cAMP, fenoterol should be used cautiously in patients with defective platelet function, in severe bleeding, and before surgery. With long-term treatment platelet aggregation may be increased and thus contribute to the formation of thrombi. Placental perfusion is not likely to be improved by increased platelet aggregation during long-term treatment with fenoterol.
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| http://dx.doi.org/10.1007/BF02108600 | DOI Listing |
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