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Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training.
Front Physiol
December 2024
Department of Biological Sciences, USC Dornsife, University of Southern California, Los Angeles, CA, United States.
Article Synopsis
- Endurance training enhances hepatic gluconeogenesis, especially in the presence of norepinephrine (NE), even without other hormones.
- Trained rat liver cells show significantly higher gluconeogenesis and lactate uptake compared to untrained controls, particularly when stimulated by NE.
- Additionally, trained hepatocytes exhibit increased glucose production in the presence of palmitate, underscoring the metabolic adaptations resulting from endurance training.
Pharmacological target sites for restoration of age-associated deficits in NMDA receptor-mediated norepinephrine release in brain.
J Neurochem
January 2025
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, District of Columbia, USA.
Aging affects virtually all organs of the body, but perhaps it has the most profound effects on the brain and its neurotransmitter systems, which influence a wide range of crucial functions, such as attention, focus, mood, neuroendocrine and autonomic functions, and sleep cycles. All of these essential functions, as well as fundamental cognitive processes such as memory, recall, and processing speed, utilize neuronal circuits that depend on neurotransmitter signaling between neurons. Glutamate (Glu), the main excitatory neurotransmitter in the CNS, is involved in most neuronal excitatory functions, including release of the neurotransmitter norepinephrine (NE).
View Article and Find Full Text PDFEndothelium-derived 6-nitrodopamine is the major mechanism by which nitric oxide relaxes the rabbit isolated aorta.
Front Pharmacol
November 2024
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
6-Nitrodopamine (6-ND) is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, with its release being significantly reduced by the NO synthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME). The vasorelaxation induced by 6-ND is unaffected by either L-NAME or the soluble guanylate cyclase (sGC) inhibitor, ODQ, indicating an alternative mechanism of action. The vasorelaxant effect appears to be mediated through selective antagonism of dopamine D receptors rather than traditional nitric oxide (NO)-mediated pathways.
View Article and Find Full Text PDFEffect of myogenic tone on agonist-mediated vasoconstriction in isolated arteries: A computational study.
Comput Methods Programs Biomed
January 2025
Department of Biotechnology and School of Electrical Sciences, Odisha University of Technology and Research, Techno Campus, Ghatikia, Bhubaneswar, 751029 Odisha, India. Electronic address:
Background And Objective: Vasoconstriction of the resistance artery is mainly determined by an integrated action of multiple local stimuli acting on the vascular smooth muscle cells, which include neuronal delivery of α-adrenoceptor agonists and intraluminal pressure. The contractile activity of the arterial wall has been extensively studied ex vivo using isolated arterial preparations and myography techniques. However, agonist-mediated vasoconstriction response is often confounded by local effects of other stimuli (e.
View Article and Find Full Text PDFEffects of sodium-glucose cotransporter-2 inhibitor on atrial high-rate episodes in patients with cardiovascular implantable electronic device: a randomized controlled trial.
Sci Rep
November 2024
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Prior research has demonstrated an association between sodium-glucose cotransporter 2 (SGLT2) inhibitor and a reduced incidence of atrial fibrillation (AF). Given the established link between mitochondrial dysfunction and AF, this study aimed to explore the impact of SGLT2 inhibitors on AF burden and plausible antiarrhythmic mechanisms in patients with cardiovascular implantable electronic devices (CIEDs). Patients with atrial high-rate episodes (AHREs) detected by CIEDs were randomized to receive either 10 mg of dapagliflozin or a placebo for 3 months.
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