The effect produced by intravenous injection of ACTH to rabbits on the content of prostaglandins E and F (PGE and PGF) in the adrenal glands was studied. At the same time a determination was made of the cAMP content in the adrenal glands and of the peripheral blood corticosterone concentration. PGE and PGF were revealed in the adrenal cortex in concentrations of 199--550 and 271--335 pg/g respectively. After a dose of 50 Units there was a 2--3-fold rise of PGE, and a 1 1/2-fold rise of the PGF content. PG synthesis was elevated maximally in the adrenal glands 15 minutes after the ACTH injection, remaining at this level for 60 minutes; similar dynamics was revealed for the cAMP and corticoterone formation. The results obtained indicated that, along with intensification of the steroids and cAMP formation, ACTH stimulated PG synthesis in the adrenal glands. These data permit a suggestion to be made that PG participated in the ACTH action on the adrenal glands.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018-2024.
Cancers (Basel)
January 2025
Department of Radiation Oncology, Miami Cancer Institute, Miami, FL 33176, USA.
: Over the past decade, significant advances have been made in image-guided radiotherapy (RT) particularly with the introduction of magnetic resonance (MR)-guided radiotherapy (MRgRT). However, the optimal clinical applications of MRgRT are still evolving. The intent of this analysis was to describe our institutional MRgRT utilization patterns and evolution therein, specifically as an early adopter within a center endowed with multiple other technology platforms.
View Article and Find Full Text PDFα-adrenoblockers modulatory effect on the noise-mediated several biochemical and morpho-immuno-histochemical changes in the rat's blood plasma and tissues.
Immunol Res
January 2025
Department of Medical Chemistry, Yerevan State Medical University After M. Heratsi, Koryun Str., 0025, Yerevan, Armenia.
Experimental studies of chronic noise exposure in modern urban life testified about oxidative stress due to the corresponding hormones effects leading to accumulation of reactive oxygen species and endothelial dysfunction. This study aims to evaluate the protective effect of α2-adrenoblockers to modulate oxidative stress and corticosterone levels due to chronic noise exposure. To achieve this, we examined the effects of beditin (2-aminothiozolyl-1,4-benzodioxane) and mesedin (2-(2-methyl-amino-thiozolyl)-1,4-benzodioxane hydrochloride), along with changes in corticosterone, Ca2 + content, and morphological alterations in various tissues under noise-induced stress.
View Article and Find Full Text PDFTransient Third-Degree Atrioventricular Block in a Dog with Addisonian Crisis.
Vet Sci
January 2025
Department of Clinics, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 700490 Iasi, Romania.
A 3-year-old spayed male mixed-breed Labrador presented to the Emergency and Critical Care Unit with lethargy, loss of appetite, vomiting, a recent history of presyncopal episodes, and severe exercise intolerance. On admission, the patient had bradycardia, low blood pressure, and mild abdominal pain. Serum biochemistry information revealed severe hyperkalemia, hyponatremia, hypoglycemia, and mildly increased liver and kidney parameters.
View Article and Find Full Text PDFDeep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis.
Curr Oncol
January 2025
Department of Radiology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Breath-hold T2-weighted half-Fourier acquisition single-shot turbo spin echo (HASTE) magnetic resonance imaging (MRI) of the upper abdomen with a slice thickness below 5 mm suffers from high image noise and blurring. The purpose of this prospective study was to improve image quality and accelerate imaging acquisition by using single-breath-hold T2-weighted HASTE with deep learning (DL) reconstruction (DL-HASTE) with a 3 mm slice thickness. MRI of the upper abdomen with DL-HASTE was performed in 35 participants (5 healthy volunteers and 30 patients) at 3 Tesla.
View Article and Find Full Text PDFHormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work.
Mol Syst Biol
January 2025
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.
Elevated cortisol in chronic stress and mood disorders causes morbidity including metabolic and cardiovascular diseases. There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic-pituitary-adrenal (HPA) axis. However, several promising HPA-modulating drugs have failed to reduce long-term cortisol in mood disorders, despite effectiveness in other hypercortisolism conditions such as Cushing's syndrome.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!