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Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease.
PLoS Negl Trop Dis
November 2024
Department of Parasitology, Biochemical and Molecular Parasitology Group CTS-183, and Institute of Biotechnology, University of Granada., Granada, Spain.
Background: Chagas disease, once restricted mainly to the Americas, Chagas disease has become a global health problem due to migration from endemic to non-endemic areas. In non-endemic regions, transmission is limited to vertical transmission from infected mothers to newborns or through blood and organ donations. A major challenge in the management of the disease lies in the diagnosis of chronic cases, as blood-borne parasites are often absent and antibodies persist for life, complicating the evaluation of treatment.
View Article and Find Full Text PDFEpidemiology and clinical description of Chagas disease in Valencia, Spain, from 2010 to 2020.
Acta Trop
December 2024
Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario y Politécnico La Fe, University of Valencia-Health Research Institute La Fe, Valencia, Spain.
Article Synopsis
- * A study at Hospital Universitari i Politécnic in Valencia, Spain, from 2010 to 2020 analyzed 3713 cases, revealing an 11.7% prevalence, primarily among women of childbearing age, with many patients undiagnosed and untreated.
- * Treatment with the drug benznidazole led to adverse reactions in 107 out of 204 patients, highlighting the challenges CD poses for healthcare systems and the importance of raising awareness about the disease.
Impact of Cognitive Intervention on Neurocognitive Development of Schoolchildren Exposed to Lead in a Semi-Urban Community in Mexico.
J Public Health Manag Pract
January 2025
Author Affiliations: National Institute of Public Health, Environmental Health Department, Cuernavaca, Morelos, Mexico (Dr Cortez-Lugo); Universidad Mayor de San Andrés, Bolivian Institute of High-Altitude Biology, La Paz, Bolivia (Ms Huanca-Laura); Environmental Health Department, National Institute of Public Health, Cuernavaca, Morelos, Mexico (Dr Hernández-Bonilla and Ms Alamo-Hernández); Universidad Autónoma de Tamaulipas, Unidad Académica Multidisciplinaria Reynosa-Aztlán, Reynosa, Tamaulipas, Mexico (Dr Montes); National Institute of Public Health, Center for Research in Evaluation and Surveys, Cuernavaca, Morelos, Mexico (Ms García-Feregrino); National Institute of Public Health, Environmental Health Department, Cuernavaca, Morelos, Mexico (Ms Velázquez); and National Institute of Neurology and Neurosurgery, Neurochemistry Department, Tlalpan, Ciudad de México, Mexico (Dr Tristán-López).
Unlabelled: Lead exposure is a severe public health issue that can adversely affect children's neurocognitive development. A semi-urban community in Mexico has been exposed to lead from food cooked in glazed clay pots. A cognitive intervention was conducted from 2015 to 2016 to minimize this negative impact.
View Article and Find Full Text PDFC-reactive protein (CRP) in high altitude Bolivian peri-urban adolescents varies by adiposity, current illness, height, socioeconomic status, sex, and menarcheal status: The potential benefits and costs of adipose reserves in arduous environments.
Am J Hum Biol
September 2024
Instituto Boliviano de Biología de Altura (IBBA), La Paz, Bolivia.
Objectives: In non-industrialized and low-income populations, adipose stores can serve as a valuable buffer against harsh conditions such as seasonal food scarcity. However, these reserves may incur costs due to adipocytes' production of pro-inflammatory cytokines; inflammation is associated with increased risk for cardiometabolic diseases later in life. Life history theory posits that, especially in populations with high juvenile mortality, higher adiposity may nonetheless be advantageous if its benefits in early life outweigh its later costs.
View Article and Find Full Text PDFGenotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes-A cross sectional study.
Environ Mol Mutagen
May 2024
Hydrosciences Montpellier, University of Montpellier, CNRS, IRD, Montpellier, France.
Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in Bolivia. Arsenic is known to cause genotoxicity but that caused by lithium and boron is less well known. The aim of the present cross-sectional study was to evaluate potential genotoxic effects of exposure to arsenic, while considering exposure to lithium and boron and genetic susceptibility.
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