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Impact of Hospital Volume on Survival for Pediatric Wilms Tumor.
Pediatr Blood Cancer
January 2025
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Treatment for children with Wilms tumor (WT) is multidisciplinary, often including surgery, chemotherapy, and sometimes radiation therapy. High-volume hospitals (HVH) have been associated with improved outcomes in cancer care. Our study evaluates the association of hospital volume and survival outcomes in pediatric WT management.
View Article and Find Full Text PDFSynchronous bilateral Wilms tumors are prone to develop independently and respond differently to preoperative chemotherapy.
Int J Cancer
December 2024
Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Children's Hospital Zhejiang University School of Medicine, Hangzhou, China.
Wilms tumor (WT) is the most common kidney cancer in infants and young children. The determination of the clonality of bilateral WTs is critical to the treatment, because lineage-independent and metastatic tumors may require different treatment strategies. Here we found synchronous bilateral WT (n = 24 tumors from 12 patients) responded differently to preoperative chemotherapy.
View Article and Find Full Text PDFBilateral Wilms Tumor - Case Report of a Patient with Family History.
Appl Clin Genet
December 2024
Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland.
Wilms' tumor (WT) is the most common renal neoplasm in children. Despite its rapid growth, it is often asymptomatic. It most commonly occurs between the ages of 3 and 5, more frequently in girls.
View Article and Find Full Text PDFA novel nephrometry scoring system outperforms RENAL score, PADUA score, and SPARE score for feasibility prediction of nephron-sparing surgery in children with bilateral Wilms tumor.
Quant Imaging Med Surg
December 2024
Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Article Synopsis
- The study aimed to assess the predictive accuracy of a new nephrometry model (RSR) for nephron-sparing surgery in pediatric patients with Wilms tumor, comparing it to existing models.
- Data from 58 pediatric patients were analyzed, calculating nephrometry scores such as RENAL, PADUA, and SPARE, and the RSR model showed superior predictive performance with an area under the curve (AUC) of 0.982.
- The RSR model not only outperformed the other nephrometry scores significantly but also demonstrated good inter-rater reliability, leading to the development of a user-friendly web-based calculator for its application.
Wilms' Tumor - An Audit.
J Indian Assoc Pediatr Surg
November 2024
Department of Pathology, Lady Hardinge Medical College and Associated Kalawati Children's Hospital, New Delhi, India.
Background And Aims: Outcome analysis of patients with Wilms' tumors (WT) is presented.
Materials And Methods: A retrospective analysis of 23 children having WT managed by a single surgeon over 3 years (2021-2024) using the International Society of Paediatric Oncology Umbrella protocol was done.
Results: The median age at presentation was 36 months; 32 months and 24 months for the unilateral WT (uWT) ( = 19) and bilateral WT (bWT) ( = 4), respectively.
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