Mouse neuroblastoma tumors show reduced amounts of cyclic adenosine 3':5'-monophosphate (cAMP) binding protein. However, the levels of cAMP-binding protein were increased by 2-fold when the tumor cells were established in tissue culture, and these levels were comparable to that found in mouse brain. This binding protein is a free cAMP-binding protein that is not associated with protein kinase. The reduced amounts of free cAMP-binding protein in tumors are not a consequence of a defective gene, but the synthesis of this protein is regulated at the transcriptional and/or translational levels. The free cAMP-binding protein like the neurotransmitter-synthesizing enzymes can be used as a biochemical marker of differentiation, and this protein may play a role in neuronal differentiation.
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Article Synopsis
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- A protein called cAMP-BP1 helps the parasite’s flagellum, which is like a tail, stay connected to its body and helps with the shape changes.
- When cAMP-BP1 is not present, the parasite has difficulty maintaining its shape and structure, which affects how it interacts with its environment.
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