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The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Göttingen Minipig Total-Body Irradiation Model.
Radiat Res
November 2020
Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland.
Animal models of total-body irradiation (TBI) are used to elucidate normal tissue damage and evaluate the efficacy of medical countermeasures (MCM). The accuracy of these TBI models depends on the reproducibility of the radiation dose-response relationship for lethality, which in turn is highly dependent on robust radiation physics and dosimetry. However, the precise levels of radiation each organ absorbs can change dramatically when different photon beam qualities are used, due to the interplay between their penetration and the natural variation of animal sizes and geometries.
View Article and Find Full Text PDFEthiopia: How the Care of 100 Million People Pivots on a Single Cobalt Teletherapy Machine.
Int J Radiat Oncol Biol Phys
February 2020
Department of Radiation Oncology, Erasmus MC, Rotterdam, Netherlands. Electronic address:
Animal models of radiation retinopathy - From teletherapy to brachytherapy.
Exp Eye Res
April 2019
Gavin Herbert Eye Institute, 850 Health Sciences Road, Irvine, CA, 92697, USA. Electronic address:
Radiation retinopathy is a serious vision-impairing complication of radiation therapy used to treat ocular tumors. Characterized by retinal vasculopathy and subsequent retinal damage, the first sign of radiation retinopathy is the preferential loss of vascular endothelial cells. Ensuing ischemia leads to retinal degradation and late stage neovascularization.
View Article and Find Full Text PDFCapacitive hyperthermia as an alternative to brachytherapy in DNA damages of human prostate cancer cell line (DU-145).
Int J Radiat Biol
February 2019
e Radiation Medicine Engineering Department , Shahid Beheshti University, Tehran , Iran .
Purpose: The aim of this study was the evaluation of induced DNA damages of human prostate cancer cells, DU-145, treated with a combination of radiofrequency capacitive hyperthermia (HT) and teletherapy (EBRT) compared to a combination of teletherapy with high-dose rate brachytherapy (BR).
Materials And Methods: DU-145 cells were cultured as spheroids in 300 micron diameter. Then the following treatments were conducted: (a) EBRT at doses of either 2 Gy or 4 Gy of photon 15 MV, (b) HT for 0, 30, 60, and 90 minutes duration at 43 °C from a 13.
Incidence of second tumours in high risk prostate cancer patients according to the primary treatment applied.
Actas Urol Esp (Engl Ed)
July 2020
Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Introduction And Objectives: The onset of second primary tumours should be considered in high-risk prostate cancer patients in the natural course of the disease. Our aim was to evaluate the influence of primary treatment with curative intent for these patients on the development of second primary tumours.
Material And Methods: A retrospective study of 286 patients diagnosed between 1996 and 2008, treated by radical prostatectomy (n=145) or radiotherapy and androgen blockade (n=141).
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