AI Article Synopsis
- Colchicine application to the sciatic nerve of newborn rats led to abnormal development in both fast and slow muscle types after one month.
- Changes were observed in the contractile and histochemical properties of the extensor digitorum longus (fast muscle) and soleus (slow muscle).
- The study highlights the crucial role of neurogenic signals from motoneurons in the differentiation of skeletal muscle fibers.
Article Abstract
Within a month after colchicine application to the sciatic nerve of a newborn rat, deviation from the normal development occurred in contractile and histochemical properties of fast (extensor digitorum longus) and slow (soleus) muscles. The data obtained revealed the importance of neurogenic agents of neurotropic control transported from pericarions of motoneurons for differentiating skeletal muscle fibers.
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