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Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis.
Front Immunol
January 2025
Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, United States.
The placenta is a unique organ with various immunological and endocrinological roles that modulate maternal and fetal physiology to promote maternal-fetal tolerance, pregnancy maintenance, and parturition at term. During pregnancy, the hormone prolactin (PRL) is constitutively secreted by the placenta and is necessary for implantation, progesterone support, fetal development, and overall immune modulation. While PRL is essential for pregnancy, studies suggest that elevated levels of serum PRL (hyperprolactinemia) are associated with adverse pregnancy outcomes, including miscarriage, preterm birth, and preeclampsia.
View Article and Find Full Text PDFMacroprolactinoma in an adolescent female with primary amenorrhoea.
Endocrinol Diabetes Metab Case Rep
October 2024
Summary: Paediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolactinoma, showing a modest radiological and biochemical response to dopamine agonist (DA) therapy. Despite a 10-month duration of increasing DA therapy, initial symptoms of primary amenorrhoea and hyperprolactinaemia persisted, with new symptoms of weight gain, lethargy and low mood.
View Article and Find Full Text PDFExploring the potential pharmacological mechanism of aripiprazole against hyperprolactinemia based on network pharmacology and molecular docking.
Schizophrenia (Heidelb)
November 2024
Computational Biology and Animal Imaging Centre (CBAC), Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Anding Hospital, Tianjin, 300222, China.
Article Synopsis
- * This study used network pharmacology and molecular docking techniques to identify molecular targets of aripiprazole and how they relate to hyperprolactinemia, finding 27 common genes and establishing a protein-protein interaction network.
- * Key proteins that aripiprazole targets include SLC6A3, MAO-B, DRD2, HTR2A, and HTR2C, which were analyzed further to understand their roles in treating
Breast Cancer risk in patients with dopamine agonist-treated hyperprolactinemia.
J Endocrinol Invest
October 2024
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Purpose: Given prolactin's (PRL) multifaceted roles in mammary tissue, an association between hyperprolactinemia and breast cancer has been hypothesized. Despite previous studies not identifying this risk, we aimed to investigate whether a connection exists.
Methods: This retrospective cohort study compared breast cancer incidence in patients with dopamine agonist (DA)-treated hyperprolactinemia versus matched controls in a 1:5 ratio.
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