Tumour cells of a patient with T-cell chronic lymphocytic leukemia had surface (E+, OKT3+, OKT4+, OKT8-, SIg-, Ia-) and cytochemical (properties positive reaction to acid phosphatase, acid nonspecific esterase and negative reaction to terminal deoxynucleotidyl transferase) specific for T-helper lymphocytes. They had no activity of NK and K-cells, reacted weakly to mitogens (PHA, Con A, PWM) and allogenic cells. Con A and PWM stimulated synthesis of specific receptors (OKT3 and OKT4) on the surface of malignant cells, whereas PHA decreased the amount of above receptors.
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