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Air quality monitoring on piloted orbital stations (OS) showed that the multicomponent air contamination largely comes from technical sources defining the quantitative and qualitative dynamics and occasional sharp surges of contamination. Another pervasive factor is secondary, more toxic compounds resulting from transformation of chemicals. The toxico-hygienic qualification of the general chemical background should be made with reference to the next functional levels: bioneutral, threshold and admissible.

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The evaluation of low-soluble particles toxicity for human phagocytes (primarily, for macrophages) was proved to have advantages in predicting their effects on the human body and in rapid toxico-hygienic regulation. The preference is given to tests "in vitro". If comparative toxicities of substances in group are discordant according to different "in vitro" tests the decision must be made after the "in vivo" evaluation of cytotoxicity: in 24 hours after the intratracheal administration of small doses of these low-soluble particles the bronchoalveolar lavage is examined cytologically.

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Toxico-hygienic studies have been carried out of a new polymeric glue to be used in the shoe-making industry. As a result of studies the use of the glue is recommended in the shoe-making industry, conditions of its safe use and the way to maintain current sanitary supervision have been suggested.

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